Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test.
Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test.
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DOI：
10.1016/j.neures.2009.10.001
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发表时间：
2010-01
影响因子：
2.9
通讯作者：
Cascella NG
中科院分区：
文献类型：
--
作者：
Ishizuka K;Tajinda K;Colantuoni C;Morita M;Winicki J;Le C;Lin S;Schretlen D;Sawa A;Cascella NG
气味识别缺陷在精神分裂症（SZ）中最常见。气味识别功能障碍与SZ阴性症状之间的关系也有报道。此外，已经发现缺陷SZ（具有原发性、持久阴性症状的疾病亚型）与气味识别测试的特别差的表现相关，表明气味识别的缺陷可以在SZ的一些亚型中差异表达。我们描述的相关性的性能气味识别与积极和消极的症状SZ。用宾夕法尼亚大学的鉴别测验（UPSIT）对SZ患者（n=15）和正常对照组（n=19）进行测试。采用阳性和阴性症状评定量表（SAPS和SANS）进行精神病理学评定。SZ患者在UPSIT测试中的表现比正常对照组差。与以前的研究结果一致，我们观察到的相关性SANS与UPSIT性能。特别是，SANS的特定子域，如迟钝的影响，冷漠和快感缺乏，与气味识别缺陷。此外，UPSIT评分可以预测阴性症状的这些子域。阳性症状和气味识别缺陷之间没有相关性。我们的研究进一步加强了嗅觉识别缺陷和SZ阴性症状之间的关系，并建议气味识别可能是一个候选的内表型相关的SZ阴性症状。
Deficits in odor identification have been the most frequently described in schizophrenia (SZ). A relationship between dysfunction in odor identification and negative symptoms of SZ has also been reported. Furthermore, deficit SZ (a subtype of the illness with primary, enduring negative symptoms) has been found to be associated with a particularly poor performance on odor identification tests indicating that deficits in smell identification could be differentially expressed in some subtypes of SZ. We describe correlations of performance on smell identification with positive and negative symptoms of SZ. Patients with SZ (n=15) and normal controls (n=19) were tested by the University of Pennsylvania Smell Identification Test (UPSIT). Psychopathology was assessed with the Scales for the Assessment of Positive and Negative Symptoms (SAPS and SANS). SZ patients performed more poorly on the UPSIT test than did normal controls. Consistent with previous findings, we observed a correlation of SANS with UPSIT performance. In particular, specific subdomains of SANS, such as blunted affect, apathy and anhedonia, were associated with odor identification deficits. Furthermore, UPSIT score predict these subdomains of negative symptoms. No correlation was observed between positive symptom and odor identification deficits. Our study further reinforces a relation between olfactory identification deficit and negative symptoms in SZ and suggests that smell identification could be a candidate endophenotype relevant to negative symptoms of SZ.
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DOI：
10.1176/appi.neuropsych.18.3.389
发表时间：
2006-06-01
影响因子：
2.9
作者：
Roalf, David R.;Turetsky, Bruce I.;Moberg, Paul J.
通讯作者：
Moberg, Paul J.
影响因子：
3.3
作者：
Borgmann-Winter KE;Rawson NE;Wang HY;Wang H;Macdonald ML;Ozdener MH;Yee KK;Gomez G;Xu J;Bryant B;Adamek G;Mirza N;Pribitkin E;Hahn CG
通讯作者：
Hahn CG
影响因子：
17.7
作者：
Milev, P;Ho, BC;Andreasen, NC
通讯作者：
Andreasen, NC
影响因子：
4.5
作者：
Corcoran, C;Whitaker, A;Malaspina, D
通讯作者：
Malaspina, D
影响因子：
2.5
作者：
GUR, RC;SKOLNICK, BE;GUR, RE
通讯作者：
GUR, RE