Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.
Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.
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DOI：
10.1016/j.dcn.2018.05.008
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发表时间：
2018-11
影响因子：
4.7
通讯作者：
Hogan TP
中科院分区：
文献类型：
--
作者：
Centanni TM;Pantazis D;Truong DT;Gruen JR;Gabrieli JDE;Hogan TP
阅读障碍儿童和非阅读障碍儿童诱发神经反应的量化变异性。部分阅读障碍儿童的大脑皮质变异性明显较高。在多个阅读网络节点中，在听觉和视觉领域观察到更高的变异性。KIAA0319的危险等位基因与听皮质的变异程度有关。结果支持不稳定的神经反应是某些阅读障碍的机制。阅读困难症患者对声音的反应表现出脑干变异性增加。目前尚不清楚变异性增加是否延伸到与听力和阅读相关的新皮质区域，是否延伸到视觉刺激，以及变异性增加是否是所有阅读障碍儿童的特征，或者相反，是特定儿童的子集。我们用脑磁图(MEG)评估了阅读障碍儿童(N = 20)和非阅读障碍儿童(N = 12)刺激诱发神经反应的一致性。大约一半的阅读障碍儿童在阅读网络的多个节点中，对听觉和视觉刺激的皮质反应的变异性水平明显更高。在所有参与者中，阅读障碍易感基因KIAA0319中rs6935076的风险等位基因数量与初级听觉皮质的神经变异程度之间存在显著的正相关关系。该基因与啮齿类动物和典型读者的神经可变性有关。这些发现表明，在阅读障碍儿童的子集中，听觉和视觉刺激在听觉和其他与阅读相关的新皮质区域的不稳定表征存在，并支持KIAA0319基因与患有或不患有阅读障碍的儿童的听神经变异性之间的联系。
Quantified variability in evoked neural responses of children with and without dyslexia. A subset of children with dyslexia had significantly higher variability in cortex. Higher variability observed in auditory and visual domains in multiple reading network nodes. Risk alleles in KIAA0319 were related to degree of variability in auditory cortex. Results support unstable neural responses as a mechanism for some cases of dyslexia. Individuals with dyslexia exhibit increased brainstem variability in response to sound. It is unknown as to whether increased variability extends to neocortical regions associated with audition and reading, extends to visual stimuli, and whether increased variability characterizes all children with dyslexia or, instead, a specific subset of children. We evaluated the consistency of stimulus-evoked neural responses in children with (N = 20) or without dyslexia (N = 12) as measured by magnetoencephalography (MEG). Approximately half of the children with dyslexia had significantly higher levels of variability in cortical responses to both auditory and visual stimuli in multiple nodes of the reading network. There was a significant and positive relationship between the number of risk alleles at rs6935076 in the dyslexia-susceptibility gene KIAA0319 and the degree of neural variability in primary auditory cortex across all participants. This gene has been linked with neural variability in rodents and in typical readers. These findings indicate that unstable representations of auditory and visual stimuli in auditory and other reading-related neocortical regions are present in a subset of children with dyslexia and support the link between the gene KIAA0319 and the auditory neural variability across children with or without dyslexia.
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影响因子：
3.7
作者：
Centanni TM;Chen F;Booker AM;Engineer CT;Sloan AM;Rennaker RL;LoTurco JJ;Kilgard MP
通讯作者：
Kilgard MP
影响因子：
2.5
作者：
Centanni, Tracy M.;King, Livia W.;Gabrieli, John D. E.
通讯作者：
Gabrieli, John D. E.
影响因子：
9.8
作者：
Cope, N;Harold, D;Williams, J
通讯作者：
Williams, J
影响因子：
3
作者：
Budd, TW;Barry, RJ;Michie, PT
通讯作者：
Michie, PT
DOI：
10.1126/science.1244333
发表时间：
2013-12-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Boets B;Op de Beeck HP;Vandermosten M;Scott SK;Gillebert CR;Mantini D;Bulthé J;Sunaert S;Wouters J;Ghesquière P
通讯作者：
Ghesquière P