A novel 3D printed mechanical actuator using centrifugal force for magnetic resonance elastography: Initial results in an anthropomorphic prostate phantom.
A novel 3D printed mechanical actuator using centrifugal force for magnetic resonance elastography: Initial results in an anthropomorphic prostate phantom.
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DOI：
10.1371/journal.pone.0205442
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Zöllner FG
中科院分区：
文献类型：
--
作者：
Neumann W;Bichert A;Fleischhauer J;Stern A;Figuli R;Wilhelm M;Schad LR;Zöllner FG
这项工作展示了一种新的方法，用于在磁共振弹性成像（MRE）过程中产生机械剪切波，该方法在较高的振动频率下产生更大的力，而不是传统使用的气动换能器。我们开发了一种MR兼容的气动涡轮机，其偏心质量可产生正弦离心力。评估了涡轮机的技术参数，并在定制的拟人前列腺体模上评价了MRE。根据流变测试检查的复合剪切模量选择体模的硅树脂基组织模拟材料。仿组织材料与人体软组织弹性值密切匹配，复合剪切模量范围为3.21 kPa至7.29 kPa。我们在3T下以50、60 Hz、70 Hz和80 Hz的激励频率采集了该体模的MRE图像。在可行性研究期间，涡轮机产生的振动波振幅足够大，足以完全穿透模型。与较软的背景材料相比，在较硬的夹杂物中检测到增加的波长。我们的初步研究结果表明，硅树脂为基础的phantomy是有用的MRE过程中的弹性评价。此外，我们的涡轮机似乎适用于MRE期间软组织的力学评估。
This work demonstrates a new method for the generation of mechanical shear wave during magnetic resonance elastography (MRE) that creates greater forces at higher vibrational frequencies as opposed to conventionally used pneumatic transducers. We developed an MR-compatible pneumatic turbine with an eccentric mass that creates a sinusoidal centrifugal force. The turbine was assessed with respect to its technical parameters and evaluated for MRE on a custom-made anthropomorphic prostate phantom. The silicone-based tissue-mimicking materials of the phantom were selected with regard to their complex shear moduli examined by rheometric testing. The tissue-mimicking materials closely matched human soft tissue elasticity values with a complex shear modulus ranging from 3.21 kPa to 7.29 kPa. We acquired MRE images on this phantom at 3 T with actuation frequencies of 50, 60 Hz, 70 Hz, and 80 Hz. The turbine generated vibrational wave amplitudes sufficiently large to entirely penetrate the phantoms during the feasibility study. Increased wave length in the stiffer inclusions compared to softer background material were detected. Our initial results suggest that silicone-based phantoms are useful for the evaluation of elasticities during MRE. Furthermore, our turbine seems suitable for the mechanical assessment of soft tissue during MRE.
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影响因子：
3.3
作者：
Arani A;Glaser KL;Arunachalam SP;Rossman PJ;Lake DS;Trzasko JD;Manduca A;McGee KP;Ehman RL;Araoz PA
通讯作者：
Araoz PA
DOI：
10.1002/jmri.25425
发表时间：
2017-04
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Morisaka H;Motosugi U;Glaser KJ;Ichikawa S;Ehman RL;Sano K;Ichikawa T;Onishi H
通讯作者：
Onishi H
影响因子：
3.3
作者：
Kolipaka, Arunark;McGee, Kiaran P.;Araoz, Philip A.;Glaser, Kevin J.;Manduca, Armando;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
4.4
作者：
Glaser, Kevin J.;Manduca, Armando;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL