Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection
Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection
复制标题
三疣梭子蟹对溶藻弧菌感染的急性代谢反应
DOI:
10.1016/j.aquaculture.2016.05.041
复制
发表时间:
2016-10
期刊:
影响因子:
4.5
通讯作者:
Wang CL
中科院分区:
文献类型:
--
作者:
Ye Yangfang;Xia Mengjie;Mu Changkao;Li Ronghua;Wang Chunlin;Ye Yangfang;Wang CL
Vibrio alginolyticusis a common pathogen that causes vibrio disease in swimming crab,Portunus trituberculatus. An understanding of the metabolic response mechanism of swimming crab toV. alginolyticusis essential for further control of this disease. In the present study, we analyzed the metabolic responses of gill, hepatopancreas, and muscle of swimming crab to an acuteV. alginolyticusinfection using1H NMR spectroscopy coupled with multivariate data analysis. Our results showed thatV. alginolyticusinfection induced significant metabolomic alterations in crab muscle and gill within 24 h. These alterations showed tissue-specific in the infected swimming crabs.V. alginolyticusinfection resulted in depression of gluconeogenesis from amino acids, improvement of energy accumulation, and enhancement of cellular immune response of muscle. These metabolic alterations were highlighted in the depletion of amino acids and inosine monophosphate as well as in the accumulation of ATP and betaine in muscle. Vibrio infection also caused energy disturbance in gill, which manifested in the depletion of glucose and in the accumulation of lactate and adenosine monophosphate. These findings provided details of acute metabolomic alterations of swimming crab afterV. alginolyticusinfection and demonstrated the potentiality of altered metabolites as biomarker in vibrio infection.Statement of relevanceProvide potential metabolite biomarkers for vibrio infection of crab.
登录
查看更多内容
影响因子:
5.2
作者:
Zavala-Norzagaray AA;Aguirre AA;Velazquez-Roman J;Flores-Villaseñor H;León-Sicairos N;Ley-Quiñonez CP;Hernández-Díaz Lde J;Canizalez-Roman A
通讯作者:
Canizalez-Roman A
影响因子:
2.9
作者:
Xie C. -Y.;Kong J. -R.;Zhao C. -S.;Xiao Y. -C.;Peng T.;Liu Y.;Wang WN
通讯作者:
Wang WN
影响因子:
4.7
作者:
Ren Xianyun;Yu Xuan;Gao Baoquan;Li Jian;Liu Ping
通讯作者:
Liu Ping
DOI:
--
发表时间:
2006-05
期刊:
--
影响因子:
--
作者:
T. Huiru;Wang Yulan
通讯作者:
T. Huiru;Wang Yulan
DOI:
--
发表时间:
2006
期刊:
--
影响因子:
--
作者:
R. A. V. D. Berg;H. Hoefsloot;J. Westerhuis;A. Smilde;M. Werf
通讯作者:
R. A. V. D. Berg;H. Hoefsloot;J. Westerhuis;A. Smilde;M. Werf