Fluoxetine and environmental enrichment similarly reverse chronic social stress-related depression- and anxiety-like behavior, but have differential effects on amygdala gene expression.
Fluoxetine and environmental enrichment similarly reverse chronic social stress-related depression- and anxiety-like behavior, but have differential effects on amygdala gene expression.
复制标题
DOI：
10.1016/j.ynstr.2021.100392
复制
发表时间：
2021-11
影响因子：
5
通讯作者：
Tamashiro KLK
中科院分区：
文献类型：
--
作者：
Cordner ZA;Marshall-Thomas I;Boersma GJ;Lee RS;Potash JB;Tamashiro KLK
The adverse effects of stress on brain and behavior have long been known and well-studied, with abundant evidence linking stress to, among other things, mood and anxiety disorders. Likewise, many have investigated potential treatments for stress-related mood and anxiety phenotypes and demonstrated good response to standard antidepressant medications like selective serotonin reuptake inhibitors (SSRIs), as well as environmental manipulations like exercise or enrichment. However, the extent to which stress and various treatments act on overlapping pathways in the brain is less well understood. Here, we used a widely studied social defeat stress paradigm to induce a robust depression- and anxiety-like phenotype and chronic corticosterone elevation that persisted for at least 4 weeks in wild type male mice. When mice were treated with either the SSRI fluoxetine or an enriched environment, both led to similar behavioral recovery from social defeat. We then focused on the amygdala and assessed the effects of social defeat, fluoxetine, and enrichment on 168 genes broadly related to synaptic plasticity or oxidative stress. We found 24 differentially expressed genes in response to social defeat stress. Interestingly, fluoxetine led to broad normalization of the stress-induced expression pattern while enrichment led to expression changes in a separate set of genes. Together, this study provides additional insight into the chronic effects of social defeat stress on behavior and gene expression in the amygdala. The findings also suggest that, for a subset of genes assessed, fluoxetine and environmental enrichment have strikingly divergent effects on expression in the amygdala, despite leading to similar behavioral outcomes. Environmental enrichment and fluoxetine result in similar recovery from stress-induced depression and anxiety-like behavior. In the amygdala, stress-related gene expression changes are broadly normalized by fluoxetine but not environmental enrichment. Environmental enrichment and fluoxetine lead to distinct sets of non-overlapping gene expression changes in the amygdala. Gene expression patterns may offer insights into complex mechanisms of stress-related psychiatric disorders and treatment.
登录
查看更多内容
DOI：
10.1523/jneurosci.1758-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Covington HE 3rd;Maze I;LaPlant QC;Vialou VF;Ohnishi YN;Berton O;Fass DM;Renthal W;Rush AJ 3rd;Wu EY;Ghose S;Krishnan V;Russo SJ;Tamminga C;Haggarty SJ;Nestler EJ
通讯作者：
Nestler EJ
影响因子：
11
作者：
Gray, A. L.;Hyde, T. M.;Sodhi, M. S.
通讯作者：
Sodhi, M. S.
DOI：
10.1002/ajmg.b.32265
发表时间：
2014-10
影响因子：
2.8
作者：
Hing, Benjamin;Gardner, Caleb;Potash, James B.
通讯作者：
Potash, James B.
影响因子：
5.3
作者：
CAMPEAU, S;DAVIS, M
通讯作者：
DAVIS, M
影响因子：
15.1
作者：
Beitia, G;Garmendia, L;Arregi, A
通讯作者：
Arregi, A