Metabolic maturation of white matter is altered in preterm infants.
Metabolic maturation of white matter is altered in preterm infants.
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DOI：
10.1371/journal.pone.0085829
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Panigrahy A
中科院分区：
文献类型：
--
作者：
Blüml S;Wisnowski JL;Nelson MD Jr;Paquette L;Panigrahy A
出生时发生显著的生理转换，例如从胎儿平行血流过渡到双回路串联系统，其中输送到包括大脑在内的所有器官的血液的动脉氧合增加。此外，子宫外环境使早产儿暴露在一系列刺激下。这些事件可能会改变早产儿大脑发育的轨迹。我们使用体内磁共振波谱法来测量足月儿和早产儿的绝对脑代谢物浓度，这些婴儿在同等的受孕后年龄时没有脑损伤的证据。早产改变了发育时间进程的N-乙酰天冬氨酸，标记轴突和神经元的发展，肌酸，能量代谢产物，胆碱，膜代谢产物，在顶叶白色的问题。具体而言，在足月等效期，早产儿的代谢成熟先于足月儿的发育，但随后以较慢的速度进展，并且在受孕后340-370天合并轨迹。在顶叶/枕叶灰质中观察到类似的趋势，但未达到统计学显著性。早产儿白色物质发育的时间和白色物质与灰质成熟的同步性受到干扰。这可能导致早产儿长期神经系统问题的风险更大，白色损伤的风险更高。
Significant physiological switches occur at birth such as the transition from fetal parallel blood flow to a two-circuit serial system with increased arterial oxygenation of blood delivered to all organs including the brain. In addition, the extra-uterine environment exposes premature infants to a host of stimuli. These events could conceivably alter the trajectory of brain development in premature infants. We used in vivo magnetic resonance spectroscopy to measure absolute brain metabolite concentrations in term and premature-born infants without evidence of brain injury at equivalent post-conceptional age. Prematurity altered the developmental time courses of N-acetyl-aspartate, a marker for axonal and neuronal development, creatine, an energy metabolite, and choline, a membrane metabolite, in parietal white matter. Specifically, at term-equivalency, metabolic maturation in preterm infants preceded development in term infants, but then progressed at a slower pace and trajectories merged at ≈340–370 post-conceptional days. In parieto/occipital grey matter similar trends were noticed but statistical significance was not reached. The timing of white matter development and synchronization of white matter and grey matter maturation in premature-born infants is disturbed. This may contribute to the greater risk of long-term neurological problems of premature infants and to their higher risk for white matter injury.
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影响因子：
3.3
作者：
Kreis, R;Hofmann, L;Hüppi, PS
通讯作者：
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