Morin incorporated polysaccharide-protein (psyllium-keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats.
Morin incorporated polysaccharide-protein (psyllium-keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats.
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DOI：
10.1039/c7ra10334d
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发表时间：
2018-01-09
期刊：
影响因子：
3.9
通讯作者：
Muthuvijayan, Vignesh
中科院分区：
文献类型：
--
作者：
Ponrasu, Thangavel;Veerasubramanian, Praveen Krishna;Kannan, Ramya;Gopika, Selvakumar;Suguna, Lonchin;Muthuvijayan, Vignesh
慢性胜利每年花费数十亿美元的公共医疗保健支出，并在全球范围内持续存在一些治疗方法目前的研究，将Morin（MOR）加载到由木马种子果壳多糖（PSH）和人毛角质（KER）制备的水凝胶支架上与钠磷酸钠交联。在脚手架上描绘了吸收多达液体干重的七倍的能力。中等胜利。一项体内糖尿病伤口愈合研究表明，PSH + KER + MOR支架治疗显着降低了上皮时间（P <0.01），并提高了速率与对照组相比，通过加速糖尿病大鼠的胶原蛋白合成来加速伤口合同（p <0.001）。
莫林负载的多糖 - 蛋白质复合支架可增强糖尿病伤口愈合。
Chronic wounds cost several billion dollars of public healthcare spending annually and continue to be a persistent threat globally. Several treatment methods have been explored, and all of them involve covering up the wound with therapeutic dressings that reduce inflammation and accelerate the healing process. In this present study, morin (MOR) was loaded onto hydrogel scaffolds prepared from psyllium seed husk polysaccharide (PSH), and human hair keratins (KER) crosslinked with sodium trimetaphosphate. ATR-FTIR confirmed the presence of the constituent chemical ingredients. SEM images of the scaffold surface reveal a highly porous architecture, with about 80% porosity measured by liquid displacement measurement, irrespective of the morin concentration. Swelling assays carried out on the scaffolds portray an ability to absorb up to seven times their dry weight of fluids. This makes them attractive for guiding moist wound healing on medium exuding wounds. An Alamar blue assay of NIH/3T3 fibroblast cells shows that cell viability decreases in the first 24 h but recovers to 85% in comparison to a control after 48 h. SEM images of fibroblast cells grown on the scaffolds confirm cellular attachment. An in vivo diabetic wound healing study showed that PSH + KER + MOR scaffold treatment significantly reduced the re-epithelialization time (p < 0.01) and enhanced the rate of wound contraction (p < 0.001), by accelerating collagen synthesis in diabetic rats compared to controls. Morin loaded polysaccharide–protein composite scaffolds enhance diabetic wound healing.
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