Multilevel modulation of a sensory motor circuit during C. elegans sleep and arousal.
Multilevel modulation of a sensory motor circuit during C. elegans sleep and arousal.
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DOI：
10.1016/j.cell.2013.11.036
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发表时间：
2014-01-16
期刊：
影响因子：
64.5
通讯作者：
Sternberg PW
中科院分区：
文献类型：
--
作者：
Cho JY;Sternberg PW
睡眠的特征是行为静止、稳态、唤醒阈值增加和快速可逆。理解这些特性是如何被神经元回路编码的一直很困难，并且没有单一的分子或神经元通路被证明负责睡眠的调节。利用映射良好的神经元连接的秀丽隐杆线虫和睡眠样状态，在这种动物，我们证明了感觉神经元和下游中间神经元介导的睡眠和觉醒的变化特性。ASH感觉神经元在类睡眠状态下对刺激的敏感性降低，并且ASH运动回路中相应的中间神经元的活动变得异步。中间神经元同步的恢复足以唤醒。所揭示的多级回路抑制提供了一种优雅的策略，以促进唤醒的稳健减少，同时允许睡眠状态的快速可逆性。
Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold, and rapid reversibility. Understanding how these properties are encoded by a neuronal circuit has been difficult, and no single molecular or neuronal pathway has been shown to be responsible for the regulation of sleep. Taking advantage of the well-mapped neuronal connections of Caenorhabditis elegans and the sleep-like states in this animal, we demonstrate the changed properties of both sensory neurons and downstream interneurons that mediate sleep and arousal. The ASH sensory neuron displays reduced sensitivity to stimuli in the sleep-like state, and the activity of the corresponding interneurons in ASH’s motor circuit becomes asynchronous. Restoration of interneuron synchrony is sufficient for arousal. The multilevel circuit depression revealed provides an elegant strategy to promote a robust decrease in arousal while allowing for rapid reversibility of the sleep state.
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影响因子：
48
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1106617108
发表时间：
2011-06-07
影响因子：
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作者：
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通讯作者：
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作者：
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