Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women.
Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women.
复制标题
DOI：
10.3390/genes13010005
复制
发表时间：
2021-12-21
期刊：
影响因子：
3.5
通讯作者：
Fuku N
中科院分区：
文献类型：
--
作者：
Takaragawa M;Tobina T;Shiose K;Kakigi R;Tsuzuki T;Ichinoseki-Sekine N;Kumagai H;Zempo H;Miyamoto-Mikami E;Kobayashi H;Naito H;Fuku N
人体肌纤维组成是异质的，主要由遗传因素决定。先前的一项研究报告说，实验诱导的大鼠缺铁增加了快缩肌纤维的比例。据报道，铁的状况受到遗传因素的影响。由于TMPRSS 6 rs 855791 T/C和HFE rs 1799945 C/G多态性与人体铁状态密切相关，我们假设基于这些多态性的基因型评分（GS）可能与人体肌纤维组成相关。在此，我们研究了214名日本人，包括107名男性和107名女性，可能的协会的GS铁状态与肌球蛋白重链（MHC）亚型（I，IIa和IIx）的比例作为肌纤维组成的标志物。在所有参与者中，铁状态的GS与MHC亚型的比例之间没有统计学显著相关性。当参与者根据性别分层时，女性的GS分别与MHC-IIa（年龄调整p = 0.020）和MHC-IIx（年龄调整p = 0.011）呈正相关和负相关。相比之下，在男性中没有发现相关性。在女性中，GS增加1分与MHC-IIa水平升高2.42%和MHC-IIx水平降低2.72%相关。我们的研究结果表明，基于TMPRSS 6 rs 855791 T/C和HFE rs 1799945 C/G多态性的GS与女性肌纤维组成相关。
Human muscle fiber composition is heterogeneous and mainly determined by genetic factors. A previous study reported that experimentally induced iron deficiency in rats increases the proportion of fast-twitch muscle fibers. Iron status has been reported to be affected by genetic factors. As the TMPRSS6 rs855791 T/C and HFE rs1799945 C/G polymorphisms are strongly associated with iron status in humans, we hypothesized that the genotype score (GS) based on these polymorphisms could be associated with the muscle fiber composition in humans. Herein, we examined 214 Japanese individuals, comprising of 107 men and 107 women, for possible associations of the GS for iron status with the proportion of myosin heavy chain (MHC) isoforms (I, IIa, and IIx) as markers of muscle fiber composition. No statistically significant correlations were found between the GS for iron status and the proportion of MHC isoforms in all participants. When the participants were stratified based on sex, women showed positive and negative correlations of the GS with MHC-IIa (age-adjusted p = 0.020) and MHC-IIx (age-adjusted p = 0.011), respectively. In contrast, no correlation was found in men. In women, a 1-point increase in the GS was associated with 2.42% higher MHC-IIa level and 2.72% lower MHC-IIx level. Our results suggest that the GS based on the TMPRSS6 rs855791 T/C and HFE rs1799945 C/G polymorphisms for iron status is associated with muscle fiber composition in women.
登录
查看更多内容
影响因子：
30.8
作者：
Chambers, John C.;Zhang, Weihua;Li, Yun;Sehmi, Joban;Wass, Mark N.;Zabaneh, Delilah;Hoggart, Clive;Bayele, Henry;McCarthy, Mark I.;Peltonen, Leena;Freimer, Nelson B.;Srai, Surjit K.;Maxwell, Patrick H.;Sternberg, Michael J. E.;Ruokonen, Aimo;Abecasis, Goncalo;Jarvelin, Marjo-Riitta;Scott, James;Elliott, Paul;Kooner, Jaspal S.
通讯作者：
Kooner, Jaspal S.
DOI：
10.1111/j.1748-1716.1975.tb10038.x
发表时间：
1975-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ESSEN, B;JANSSON, E;SALTIN, B
通讯作者：
SALTIN, B
影响因子：
4.5
作者：
Faucher, M;Guillot, C;Badier, M
通讯作者：
Badier, M
影响因子：
6.5
作者：
Gerrits, Martin F.;Ghosh, Sujoy;Harper, Mary-Ellen
通讯作者：
Harper, Mary-Ellen
影响因子：
2.7
作者：
Ahmetov, Ildus I.;Druzhevskaya, Anastasiya M.;Williams, Alun G.
通讯作者：
Williams, Alun G.