[Effects of peri- and postnatal lead administration on learning of high avoider rats].
[Effects of peri- and postnatal lead administration on learning of high avoider rats].
复制标题
围产期和产后铅给药对高回避大鼠学习的影响。
DOI：
10.1539/joh1959.28.428
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Shigeta
中科院分区：
文献类型：
--
作者：
H. Aikawa;K. Suzuki;T. Misawa;H. Momotani;S. Shigeta
在具有高水平回避能力和小个体差异的幼年和成年大鼠（THA大鼠：东海高回避大鼠）中评价了醋酸铅给药对Sidman回避行为的影响。THA大鼠从妊娠第13天开始经口灌胃给予醋酸铅，在断奶前经母乳给予醋酸铅溶液200-300 mg/kg/d，直至7周龄。分别于生后49、100、150 d进行3组Sidman回避行为试验，每组10 d，每天1 h。在第一个系列中，一个显着的延迟休克回避收购观察铅管理的雄性大鼠与对照组相比，而没有收购延迟被视为在雌性大鼠。染铅雄性大鼠可分为两组，具有不同的反应模式：低敏感组（LSG），表现出良好的收购率从一开始就类似于对照组和高敏感组（HSG），表现出显着的延迟和个体差异。在第二个试验系列中，除雄性HSG外，所有试验组均获得了非常高的回避率，但在第三个试验系列中，雄性HSG也获得了高回避率的最终获得。各组之间没有发育差异，也没有暴露组器官铅含量的差异。THA大鼠的行为毒理学有用的特点进行了讨论。
Effects of administration of lead acetate on Sidman avoidance behavior were assessed in juvenile and adult rats which were obtained by continued selective breeding and which have a high level avoidance ability and small individual differences (THA rat: Tokai high avoider rat). THA rats were administered lead acetate solution at 200-300 mg/kg/day as Pb until 7 wk of age through maternal milk before weaning from mothers which had been administered lead acetate from the 13th day of gestation and per os by gastric tube after weaning. Three series of Sidman avoidance behavior tests were conducted from 49th, 100th and 150th day after birth each for 10 d, 1 h every day. In the first series, a significant delay of shock avoidance acquisition was observed in lead-administered male rats compared with the control subjects, while no acquisition delay was seen in female rats. The lead administered male rats could be divided into two groups with different response patterns; a low susceptible group (LSG) which exhibited as good acquisition rate from the beginning similar to the control rats and a high susceptible group (HSG) which showed a significant delay and individual differences. In the 2nd test series, very high avoidance rates were obtained in all the test groups except in male HSG, but in the 3rd test series, male HSG also attained a final acquisition of high avoidance rate. There was no developmental variation between the groups nor difference in lead contents of the organs of the exposed group. Useful characteristics of THA rats for behavioral toxicology are discussed.
铅暴露大鼠造血参数与行为测量之间的关系。
影响因子：
3.8
作者：
Hastings,L;Zenick,H;Succop,P;Sun,TJ;Sekeres,R
通讯作者：
Sekeres,R
影响因子：
3.8
作者：
Harry,GJ;Toews,AD;Krigman,MR;Morell,P
通讯作者：
Morell,P
断奶前后暴露于铅的大鼠的操作行为。
影响因子：
3.8
作者：
Angell,NF;Weiss,B
通讯作者：
Weiss,B