The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia.
The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia.
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DOI：
10.1186/s12890-016-0324-z
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发表时间：
2016-12-01
影响因子：
3.1
通讯作者：
da Silva GA
中科院分区：
文献类型：
--
作者：
de Brito RC;Lucena-Silva N;Torres LC;Luna CF;Correia JB;da Silva GA
为了确定早期诊断重症肺炎的标志物，我们评估了不同肺炎严重程度的儿童血清细胞因子谱之间的相关性。在25名住院儿童中，7名患有轻度肺炎，18名患有重度肺炎，在三个采样时间测定了11种细胞因子的血清浓度。统计学分析包括参数和非参数检验、Pearson相关分析和ROC曲线，以确定细胞因子的临界值。入院时，轻度或重度肺炎患者血清IL-6水平较高，两组患者均与呕吐相关（P = 0.019）;重度肺炎患者也与呼吸困难（P = 0.012）和白色血细胞计数（P = 0.045）相关。肺炎患者的IL-10水平也较高，与淋巴细胞增多相关（P = 0.025）。IL-6：IL-10血清水平比值的ROC曲线区分了入院时的重症肺炎病例和抗生素治疗第3天的持续感染，阳性预测值分别为93%和89%。IL-6和IL-10血清水平之间的平衡被证明是肺炎患者严重程度定义和恢复评估的更具区分性的标志物。本文的在线版本（doi：10.1186/s12890-016-0324-z）包含补充材料，可供授权用户使用。
To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity. In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines. At admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0.019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025). The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively. The balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity definition and evaluation of recovery in patients with pneumonia. The online version of this article (doi:10.1186/s12890-016-0324-z) contains supplementary material, which is available to authorized users.
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影响因子：
3.6
作者：
Cevey-Macherel M;Galetto-Lacour A;Gervaix A;Siegrist CA;Bille J;Bescher-Ninet B;Kaiser L;Krahenbuhl JD;Gehri M
通讯作者：
Gehri M
影响因子：
5.7
作者：
Deng, JC;Standiford, TJ
通讯作者：
Standiford, TJ
影响因子：
1.4
作者：
Don, Massimiliano;Valent, Francesca;Canciani, Mario
通讯作者：
Canciani, Mario
影响因子：
3.1
作者：
Michelow, Ian C.;Katz, Kathy;Hardy, R. Doug
通讯作者：
Hardy, R. Doug
影响因子：
5.7
作者：
Alcón, A;Fábregas, N;Torres, A
通讯作者：
Torres, A