Dopamine, effort, and decision making: theoretical comment on Bardgett et al. (2009).
Dopamine, effort, and decision making: theoretical comment on Bardgett et al. (2009).
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多巴胺、努力和决策：Bardgett 等人的理论评论。
DOI：
10.1037/a0015381
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发表时间：
2009
影响因子：
1.9
通讯作者：
Salamone,JohnD
中科院分区：
文献类型：
--
作者：
Salamone,JohnD
前脑多巴胺（DA）系统被认为是大脑回路中调节行为激活、工具性行为中的工作输出和与努力相关的决策的关键组成部分。让动物在需要不同程度努力的选项之间做出选择的任务，可以用来评估与努力相关的选择行为。使用DA拮抗剂或伏隔核DA消耗的大鼠倾向于减少对高反应要求的工具性行为的选择，相反，它们选择参与较少努力的觅食行为。Bardgett等人的文章（见记录2009-04037-002）描述了一种新的努力折扣任务，该任务涉及对先前开发的t迷宫选择程序的修改（Salamone等人，1994）。迷宫的每一部分都包含不同程度的食物强化，为了获得更高程度的奖励，老鼠必须爬上迷宫那一部分的屏障。经过训练，大鼠能够不断爬上更高的障碍物以获得更多的食物，在高屏障臂和奖励较小的无屏障臂之间的选择可以作为评估多巴胺能药物效果的模板。D1和D2家族拮抗剂，以及DA释放剂安非他明，能够产生选择行为的双向调节，而作用于D3受体的药物无效。这些研究阐明了努力相关决策的神经化学调节特征，并可能对理解动机的自然和病理特征具有启示意义。（PsycInfo数据库记录(c) 2023 APA，版权所有）
Forebrain dopamine (DA) systems are thought to be a critical component of the brain circuitry regulating behavioral activation, work output during instrumental behavior, and effort-related decision making. Tasks that offer animals choices between alternatives that require different degrees of effort can be used to assess effort-related choice behavior. Rats treated with DA antagonists, or with accumbens DA depletions, tend to show reduced selection of instrumental behaviors with high response requirements, and instead they choose to engage in food-seeking behaviors that involve less effort. The accompanying article by Bardgett et al.(see record 2009-04037-002) describes a novel effort-discounting task that involves the modification of a previously developed T-maze choice procedure (Salamone et al., 1994). Each arm of the maze contained different magnitudes of food reinforcement, and in order to obtain the higher magnitude reward, the rats had to climb a barrier in that arm of the maze. With training, rats were able to climb successively higher barriers to obtain the larger amount of food, and the choice between the high barrier arm and the no-barrier arm with the smaller reward served as a template for assessing the effects of dopaminergic drugs. D1 and D2 family antagonists, as well as the DA releasing agent amphetamine, were able to produce a bidirectional modulation of choice behavior, while drugs that act on D3 receptors were ineffective. These studies illustrate features of the neurochemical regulation of effort-related decision making, and may have implications for the understanding of both natural and pathological features of motivation.(PsycInfo Database Record (c) 2023 APA, all rights reserved)
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影响因子：
1.9
作者：
Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
通讯作者：
Green, Leonard
影响因子：
1.9
作者：
Schweimer, J;Saft, S;Hauber, W
通讯作者：
Hauber, W
多巴胺能参与动机的激活方面：氟哌啶醇对大鼠日程诱导的活动、进食和觅食的影响
DOI：
10.3758/bf03327307
发表时间：
1988
期刊：
Psychobiology
影响因子：
--
作者：
J. Salamone
通讯作者：
J. Salamone
中脑多巴胺在激活中的作用：Berridge 评论 (2006)
影响因子：
3.4
作者：
T. Robbins;B. Everitt
通讯作者：
B. Everitt
影响因子：
3.4
作者：
Koch, M;Schmid, A;Schnitzler, HU
通讯作者：
Schnitzler, HU