A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers.
A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers.
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DOI：
10.3791/56097
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发表时间：
2018-01-05
期刊：
影响因子：
--
通讯作者：
Kamboj SK
中科院分区：
文献类型：
--
作者：
Das RK;Gale G;Hennessy V;Kamboj SK
适应不良奖励记忆（MRM）在某些条件下会在提取后变得不稳定，从而允许随后的新学习对其进行修改。然而，强大的（排练好）和按时间顺序排列的旧MRM，如那些潜在的物质使用障碍，不容易不稳定时检索。在提取过程中记忆不稳定的一个关键决定因素是预测误差（PE）。我们描述了一个检索程序，酒精MRM在危险的饮酒者，特别是旨在最大限度地产生PE，因此MRM不稳定的可能性。该程序需要明确地产生预期的酒精消费，然后违反这一预期（抑制酒精）的一组简短的原型酒精提示图像（检索+ PE）的介绍。控制程序涉及呈现相同的提示图像，但允许酒精被消耗，产生最小的PE（检索-无PE）或通过呈现橙子汁提示（无检索+ PE）在不检索酒精MRM的情况下产生PE。随后，我们描述了一个多感官厌恶为基础的反调节程序，以探测MRM不稳定重写酒精线索奖励协会之前，重新巩固。这一过程将酒精线索与引起病原体厌恶的图像和一种味道极淡的溶液（苯甲酸地那铵）配对，产生味觉厌恶。检索+ PE后，但不是没有检索+ PE或检索没有PE，反调节产生的证据MRM重写索引持久减少酒精线索估值，注意力捕获，酒精渴望。
Maladaptive reward memories (MRMs) can become unstable following retrieval under certain conditions, allowing their modification by subsequent new learning. However, robust (well-rehearsed) and chronologically old MRMs, such as those underlying substance use disorders, do not destabilize easily when retrieved. A key determinate of memory destabilization during retrieval is prediction error (PE). We describe a retrieval procedure for alcohol MRMs in hazardous drinkers that specifically aims to maximize the generation of PE and therefore the likelihood of MRM destabilization. The procedure requires explicitly generating the expectancy of alcohol consumption and then violating this expectancy (withholding alcohol) following the presentation of a brief set of prototypical alcohol cue images (retrieval + PE). Control procedures involve presenting the same cue images, but allow alcohol to be consumed, generating minimal PE (retrieval-no PE) or generate PE without retrieval of alcohol MRMs, by presenting orange juice cues (no retrieval + PE). Subsequently, we describe a multisensory disgust-based counterconditioning procedure to probe MRM destabilization by re-writing alcohol cue-reward associations prior to reconsolidation. This procedure pairs alcohol cues with images invoking pathogen disgust and an extremely bitter-tasting solution (denatonium benzoate), generating gustatory disgust. Following retrieval + PE, but not no retrieval + PE or retrieval-no PE, counterconditioning produces evidence of MRM rewriting as indexed by lasting reductions in alcohol cue valuation, attentional capture, and alcohol craving.
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影响因子：
2.7
作者：
Agustina Lopez, M.;Jimena Santos, M.;Pedreira, Maria E.
通讯作者：
Pedreira, Maria E.
影响因子：
25
作者：
Kindt, Merel;Soeter, Marieke;Vervliet, Bram
通讯作者：
Vervliet, Bram
DOI：
10.1523/jneurosci.3273-12.2013
发表时间：
2013-01-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Milton AL;Merlo E;Ratano P;Gregory BL;Dumbreck JK;Everitt BJ
通讯作者：
Everitt BJ
影响因子：
2.7
作者：
Barreiro, Karina A.;Suarez, Luis D.;Delorenzi, Alejandro
通讯作者：
Delorenzi, Alejandro
DOI：
10.1101/lm.1912510
发表时间：
2010-10-01
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Chan, Wan Yee Macy;Leung, Hiu T;McNally, Gavan P
通讯作者：
McNally, Gavan P