Mice with gene alterations in the GH and IGF family.
Mice with gene alterations in the GH and IGF family.
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DOI：
10.1007/s11102-021-01191-y
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发表时间：
2022-03
期刊：
影响因子：
3.8
通讯作者：
Kopchick JJ
中科院分区：
文献类型：
--
作者：
Qian Y;Berryman DE;Basu R;List EO;Okada S;Young JA;Jensen EA;Bell SRC;Kulkarni P;Duran-Ortiz S;Mora-Criollo P;Mathes SC;Brittain AL;Buchman M;Davis E;Funk KR;Bogart J;Ibarra D;Mendez-Gibson I;Slyby J;Terry J;Kopchick JJ
我们对生长激素作用的理解大多来自动物模型以及遗传改变或修饰小鼠的产生和表征。动物中GH/IGF 1家族基因的操作始于1982年，当时产生了第一只GH转基因小鼠。从那时起，多个实验室已经改变了小鼠DNA，以全面破坏Gh，Ghr和GH或其受体上游或下游的其他基因。在GH/IGF 1研究领域内保持与各种遗传操纵小鼠品系同步的能力令人望而生畏。因此，本综述试图巩固和总结的文献相关的许多已知的基因操作的小鼠有关GH，PRL和IGF 1的行动的初步表征。我们通过对GHR上游或下游或GHR本身的GH/IGF 1家族的成分进行修饰来组织小鼠品系。现有的数据对改变基因表达对生长，生长激素/胰岛素样生长因子1水平，身体组成，生殖，糖尿病，代谢，癌症和衰老的影响进行了总结。为了便于查找该信息，在正文中每一鼠标行的关键词均以粗体突出显示，该信息总结于表1、2、3和4中。最重要的是，来自这些小鼠的集体数据和报告增强了我们对GH作用的理解。
Much of our understanding of GH’s action stems from animal models and the generation and characterization of genetically altered or modified mice. Manipulation of genes in the GH/IGF1 family in animals started in 1982 when the first GH transgenic mice were produced. Since then, multiple laboratories have altered mouse DNA to globally disrupt Gh, Ghr, and other genes upstream or downstream of GH or its receptor. The ability to stay current with the various genetically manipulated mouse lines within the realm of GH/IGF1 research has been daunting. As such, this review attempts to consolidate and summarize the literature related to the initial characterization of many of the known gene-manipulated mice relating to the actions of GH, PRL and IGF1. We have organized the mouse lines by modifications made to constituents of the GH/IGF1 family either upstream or downstream of GHR or to the GHR itself. Available data on the effect of altered gene expression on growth, GH/IGF1 levels, body composition, reproduction, diabetes, metabolism, cancer, and aging are summarized. For the ease of finding this information, key words are highlighted in bold throughout the main text for each mouse line and this information is summarized in Tables 1, 2, 3 and 4. Most importantly, the collective data derived from and reported for these mice have enhanced our understanding of GH action.
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影响因子：
4.8
作者：
Al-Regaiey, KA;Masternak, MM;Bartke, A
通讯作者：
Bartke, A
影响因子：
4
作者：
BEAMER, WG;EICHER, EM
通讯作者：
EICHER, EM
影响因子：
64.5
作者：
BAKER, J;LIU, JP;EFSTRATIADIS, A
通讯作者：
EFSTRATIADIS, A
影响因子：
14.9
作者：
BARSH, GS;SEEBURG, PH;GELINAS, RE
通讯作者：
GELINAS, RE
影响因子：
64.8
作者：
Bartke, A;Wright, JC;Roth, GS
通讯作者：
Roth, GS