Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress.
Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress.
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DOI：
10.1007/s00213-020-05657-y
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发表时间：
2021-01
影响因子：
3.4
通讯作者：
Lobo MK
中科院分区：
文献类型：
--
作者：
Engeln M;Fox ME;Lobo MK
压力暴露会对动机行为产生持久的影响，并会加剧现有的物质使用障碍的脆弱性。已经开发了几个模型来研究压力经历如何塑造药物奖励。这些因素从运动敏感化和条件性位置偏好，到药物自我给药的倾向或对药物预测线索的反应。虽然自我给药研究被认为具有更多的翻译相关性，但到目前为止，大多数研究都是在老鼠身上进行的。此外，许多自我管理的研究都是在单独饲养的动物身上进行的，这增加了社会孤立的额外压力。我们试图确定慢性社会失败压力(CSDS)和社会住房条件如何影响C57BL/6小鼠的可卡因自我管理和寻找可卡因的行为。我们评估了C57BL/6小鼠的自我给药行为(可卡因或生理盐水，0.5 mg/kg/次输液)，这些小鼠接受了10天的CSDS或非应激对照组。在自我给药期间，小鼠要么成对饲养，要么被隔离。我们比较了住房在获得自我管理、寻求、灭绝、药物诱导的恢复以及再次暴露于社会应激源之后的影响。自我给药期间的配对住房显示，在CSD与可卡因摄入量减少相关后，社交回避增加。相比之下，独栋住宅显示出对压力敏感的可卡因摄入量，在CSD后社交回避增加与早期可卡因摄入量增加相关。成对但不是单一住所的小鼠容易受到药物诱导的恢复，而不受CSDS病史的影响。应激再暴露敏化应激独居小鼠的可卡因寻找。在心理社会应激后，可卡因摄入的社会背景可以双向影响与可卡因相关的行为，在研究应激和药物交叉敏化时应予以考虑。
Stress exposure has a lasting impact on motivated behavior and can exacerbate existing vulnerabilities for developing a substance use disorder. Several models have been developed to examine how stressful experiences shape drug-reward. These range from locomotor sensitization and conditioned place preference, to the propensity for drug self-administration or responding to drug-predictive cues. While self-administration studies are considered to have more translational relevance, most of the studies to date have been conducted in rats. Further, many self-administration studies are conducted in single-housed animals, adding the additional stressor of social isolation. We sought to establish how chronic social defeat stress (CSDS) and social housing conditions impact cocaine self-administration and cocaine-seeking behaviors in C57BL/6 mice. We assessed self-administration behavior (cocaine or saline, 0.5 mg/kg/infusion) in C57BL/6 mice subjected to 10 days CSDS or in unstressed controls. Mice were either housed in pairs or in isolation during self-administration. We compared the effect of housing on acquisition of self-administration, seeking, extinction, drug-induced reinstatement, and after re-exposure to the social stressor. Pair-housing during self-administration revealed increased social avoidance after CSDS is associated with decreased cocaine intake. In contrast, single-housing revealed stress-sensitive cocaine intake, with increased social avoidance after CSDS associated with increased early cocaine intake. Pair-, but not single-housed mice are susceptible to drug-induced reinstatement independent of CSDS history. Stress re-exposure sensitized cocaine-seeking in stressed single-housed mice. The social context surrounding cocaine intake can bidirectionally influence cocaine-related behaviors after psychosocial stress and should be considered when studying stress and drug cross-sensitization.
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影响因子：
10.6
作者：
Engeln M;Mitra S;Chandra R;Gyawali U;Fox ME;Dietz DM;Lobo MK
通讯作者：
Lobo MK
影响因子：
3.4
作者：
Han, Xiao;Albrechet-Souza, Lucas;Doyle, Michelle R.;Shimamoto, Akiko;DeBold, Joseph F.;Miczek, Klaus A.
通讯作者：
Miczek, Klaus A.
影响因子：
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作者：
Hatzigiakoumis DS;Martinotti G;Giannantonio MD;Janiri L
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Janiri L
影响因子：
3.4
作者：
Burke AR;Miczek KA
通讯作者：
Miczek KA
影响因子：
11
作者：
Francis TC;Chandra R;Gaynor A;Konkalmatt P;Metzbower SR;Evans B;Engeln M;Blanpied TA;Lobo MK
通讯作者：
Lobo MK