First demonstration of real-time in-situ dosimetry of X-ray microbeams using a large format CMOS sensor
First demonstration of real-time in-situ dosimetry of X-ray microbeams using a large format CMOS sensor
复制标题
首次演示使用大幅面 CMOS 传感器对 X 射线微束进行实时原位剂量测定
DOI：
10.1016/j.nima.2020.164395
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发表时间：
2020
影响因子：
1.4
通讯作者：
Jacobs-Headspith J
中科院分区：
文献类型：
--
作者：
Flynn S;Price T;Allport PP;Patallo;Thomas R;Subiel A;Bartzsch S;Treibel F;Ahmed M;Jacobs-Headspith J
微束放射治疗是一种新型放射治疗，其中窄辐射束（通常小于500 μ m）在空间上被分割，向靶肿瘤体积提供非均匀分布。由于所涉及的剂量梯度非常高且射束非常小，因此需要新的剂量测定技术来转化为临床实践。目前的实时射束监测通常使用一维硅条检测器或线室进行，使用辐射变色胶片离线测量2D射束信息（需要至少24小时自行显影）。使用慕尼黑工业大学（德国）配备定制微束准直器的Xstrahl SARRP X射线辐照设备，将新开发的vM 1212探测器暴露于各种微束（220 kV，标称狭缝宽度0-100 μ m），以评价体内真实的时间验证。通过改变准直器狭缝宽度（以及因此微束FWHM）中间照射来评估检测器的性能。用这种方法可以测量130-190 μ m的微束半高宽，同时还可以实时监测其他基本参数，如辐射强度。当微束准直器内的钨狭缝打开和关闭时，可以计算更高级的参数，例如FWHM的变化率;峰谷剂量比（PVDR）;以及每个微束峰的亚像素移动。这项工作表明了辐射硬CMOS传感器在放射治疗中的潜力，用于在体内实时监测X射线微束的半高宽，强度和位置。
Microbeam radiotherapy is a novel type of radiotherapy in which narrow beams of radiation (typically less than 500 μ m) are spatially fractionated, delivering a non-uniform distribution to the target tumour volume. Due to the very high dose gradients and very small beams involved, new dosimetric techniques are required for translation into clinical practise. Current real-time beam monitoring is typically performed using 1 dimensional silicon strip detectors or wire chambers, with 2D beam information measured offline using radiochromic film (requiring a minimum of 24 h to self-develop). Using an Xstrahl SARRP X-ray irradiation device with a bespoke microbeam collimator at the Technical University of Munich, Germany, the newly developed vM1212 detector was exposed to a variety of microbeams (220 kV, nominal slit widths 0–100 μ m) for evaluation of in vivo real time verification. The performance of the detector was assessed by changing the collimator slit width (and thus microbeam FWHM) mid-irradiation. Microbeam FWHMs of 130–190 μ m could be measured in this manner in addition to temporally monitoring other basic parameters such as the radiation intensity. More advanced parameters could be calculated as the tungsten slits within the microbeam collimator opened and closed such as the rate of change of FWHM; the peak–valley-dose-ratio (PVDR); and the sub-pixel movement of each microbeam peak. This work demonstrates the potential of radiation hard CMOS sensors in radiotherapy for in vivo real-time monitoring of X-ray microbeams FWHM, intensity and position.
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影响因子：
3.8
作者：
Bartzsch S;Cummings C;Eismann S;Oelfke U
通讯作者：
Oelfke U
影响因子：
3.8
作者：
Flynn, Samuel;Price, Tony;Sedgwick, Iain
通讯作者：
Sedgwick, Iain
影响因子：
3.5
作者：
Regnard, Pierrick;Le Duc, Geraldine;Bravin, Alberto
通讯作者：
Bravin, Alberto
用于微束放射治疗中束流监测的薄硅条探测器
影响因子：
1.3
作者：
M. Povoli;E. Alagoz;Alberto Bravin;I. Cornelius;E. Brauer;Pauline Fournier;Thor;A. Kok;M. Lerch;E. Monakhov;John Morse;M. Petasecca;H. Requardt;A. Rosenfeld;D. Røhrich;H. Sandaker;Murielle Salom'e;B. Stugu
通讯作者：
B. Stugu
DOI：
10.1016/j.ejmp.2015.04.016
发表时间：
2015-09-01
影响因子：
3.4
作者：
Braeuer-Krisch, Elke;Adam, Jean-Francois;Stugu, Bjarne
通讯作者：
Stugu, Bjarne