Advances in the Arms Race Between Silkworm and Baculovirus.

Advances in the Arms Race Between Silkworm and Baculovirus.
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DOI:
10.3389/fimmu.2021.628151
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发表时间:
2021
影响因子:
7.3
通讯作者:
Xia Q
Xia Q
中科院分区:
医学2区
文献类型:
--
作者:
Jiang L;Goldsmith MR;Xia Q

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昆虫是最大的动物类群。几乎所有生物体,包括昆虫,都具有病毒病原体。一种重要的驯化经济昆虫是蚕蛾Bombyx mori。家蚕核多角体病毒(BmNPV)是一种典型的杆状病毒,也是家蚕的主要病原体。给蚕桑业造成重大经济损失。杆状病毒用于生物害虫控制并用作生物反应器。蚕和杆状病毒构成了昆虫-病毒相互作用的成熟模型。最近的几项研究集中在该模型上,并为病毒感染和宿主防御提供了新的见解。在此,我们重点关注杆状病毒的入侵、家蚕的免疫反应、杆状病毒逃避宿主免疫以及增强抗病毒功效。我们还讨论了家蚕抗病毒免疫研究中尚存的主要问题和未来的方向。阐明家蚕和杆状病毒之间的相互作用,为害虫的针对性防治、增强经济重要昆虫的病原体抗性以及生物反应器的改进提供了理论基础。
Insects are the largest group of animals. Nearly all organisms, including insects, have viral pathogens. An important domesticated economic insect is the silkworm moth Bombyx mori. B. mori nucleopolyhedrovirus (BmNPV) is a typical baculovirus and a primary silkworm pathogen. It causes major economic losses in sericulture. Baculoviruses are used in biological pest control and as a bioreactor. Silkworm and baculovirus comprise a well-established model of insect–virus interactions. Several recent studies have focused on this model and provided novel insights into viral infections and host defense. Here, we focus on baculovirus invasion, silkworm immune response, baculovirus evasion of host immunity, and enhancement of antiviral efficacy. We also discuss major issues remaining and future directions of research on silkworm antiviral immunity. Elucidation of the interaction between silkworm and baculovirus furnishes a theoretical basis for targeted pest control, enhanced pathogen resistance in economically important insects, and bioreactor improvement.
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