Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.
Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.
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实体器官移植受者与免疫功能正常患者的菌血症比较：一项前瞻性、配对队列研究中的急性期细胞因子和结果。
DOI：
10.1111/ajt.16388
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Maskarinec SA
中科院分区：
文献类型：
--
作者：
Eichenberger EM;Ruffin F;Dagher M;Lerebours R;Jung SH;Sharma-Kuinkel B;Macintyre AN;Thaden JT;Sinclair M;Hale L;Kohler C;Palmer SM;Alexander BD;Fowler VG Jr;Maskarinec SA
我们对金黄色葡萄球菌菌血症（SAB）和革兰氏阴性菌血症（GNB）患者进行了一项前瞻性配对队列研究，以比较移植受者与免疫功能正常的非移植受者的特征、结局以及趋化因子和细胞因子反应。55例移植受者（GNB n=29; SAB n=26）和225例非移植受者（GNB n=114; SAB n=111）被纳入临床分析。移植GNB的感染性休克发生率显著低于非移植GNB（10.3% vs 30.7%，p=0.03）。30天死亡率在GNB（10.3% vs 15.8%，p=0.57）或SAB（0.0% vs 11.7%，p=0.13）移植和非移植受者之间没有显著差异。接下来，将移植患者与非移植患者1：1匹配进行趋化因子和细胞因子分析。与非移植GNB相比，移植GNB中的五种细胞因子和趋化因子显著降低：（中位数[IQR]：7.1 pg/mL [7.1，7.1] vs 32.6 pg/mL [7.1，88.0]; p=0.001），MIP-1β（30.7 pg/mL [30.7，30.7] vs 243.3 pg/mL [30.7，344.4]; p=0.001），IL-8（32.0 pg/mL [5.6，53.1] vs 59.1 pg/mL [39.2，119.4]; p=0.003），IL-15（12.0 pg/mL [12.0，12.0] vs 12.0 pg/mL [12.0，126.7]; p=0.03）和IFN-α（5.1 pg/mL [5.1，5.1] vs 5.1 pg/mL [5.1，26.3]; p=0.04）。与非移植SAB相比，移植SAB中调节活化的正常T细胞表达和分泌（RANTES）更高（平均值[SD]：750.2pg/mL [194.6] vs 656.5pg/mL [147.6]; p=0.046）。
We undertook a prospective matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes and chemokine and cytokine response in transplant recipients to immunocompetent, non-transplant recipients. Fifty-five transplant recipients (GNB n=29; SAB n=26) and 225 non-transplant recipients (GNB n=114; SAB n=111) were included for clinical analysis. Transplant GNB had a significantly lower incidence of septic shock than non-transplant GNB (10.3% vs 30.7%, p=0.03). Thirty-day mortality did not differ significantly between transplant and non-transplant recipients with GNB (10.3% vs 15.8%, p=0.57) or SAB (0.0% vs 11.7%, p=0.13). Next, transplant patients were matched 1:1 with non-transplant patients for the chemokine and cytokine analysis. Five cytokines and chemokines were significantly lower in transplant GNB vs non-transplant GNB: IL-2 (median [IQR]: 7.1pg/mL [7.1, 7.1] vs 32.6pg/mL [7.1, 88.0]; p=0.001), MIP-1β (30.7pg/mL [30.7, 30.7] vs 243.3pg/mL [30.7, 344.4]; p=0.001), IL-8 (32.0pg/mL [5.6, 53.1] vs 59.1pg/mL [39.2, 119.4]; p=0.003), IL-15 (12.0pg/mL [12.0, 12.0] vs 12.0pg/mL [12.0, 126.7]; p=0.03), and IFN-α (5.1pg/mL [5.1, 5.1] vs 5.1pg/mL [5.1, 26.3]; p=0.04). Regulated on Activation Normal T Cell Expressed and Secreted (RANTES) was higher in transplant SAB vs non-transplant SAB (mean [SD]: 750.2pg/mL [194.6] vs 656.5pg/mL [147.6]; p=0.046).
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DOI：
10.1186/cc11454
发表时间：
2013-02-04
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kellum JA;Lameire N;KDIGO AKI Guideline Work Group
通讯作者：
KDIGO AKI Guideline Work Group
影响因子：
14.2
作者：
Magiorakos, A. -P.;Srinivasan, A.;Monnet, D. L.
通讯作者：
Monnet, D. L.
影响因子：
16.8
作者：
Appay, V;Rowland-Jones, SL
通讯作者：
Rowland-Jones, SL
影响因子：
6.2
作者：
Malinis, Maricar F.;Mawhorter, Steven D.;van Duin, David
通讯作者：
van Duin, David
影响因子：
11.8
作者：
Souli, Maria;Ruffin, Felicia;Fowler, Vance G., Jr.
通讯作者：
Fowler, Vance G., Jr.