Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization.
Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization.
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二氧化钛纳米管通过抑制巨噬细胞糖酵解促进M2极化，最终加速内皮化
DOI：
10.1002/iid3.429
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Zhou JL
中科院分区：
文献类型：
--
作者：
Yu WP;Ding JL;Liu XL;Zhu GD;Lin F;Xu JJ;Wang Z;Zhou JL
钛已广泛用于人工瓣膜，但它们与钛基人工瓣膜的严重缺陷相关，如血栓形成、钙化和腐烂。因此，对钛基瓣膜进行生物功能化，以减少炎症，加速支架内皮化和抗血栓形成非常重要。采用阳极氧化法以纯钛为原料制备了二氧化钛纳米管。研究了二氧化钛纳米管作为植入物对巨噬细胞代谢和炎症反应的影响。分析巨噬细胞的极化状态和促进内皮化的能力。结果表明，钛纳米管通过抑制糖酵解和激活腺苷一磷酸活化蛋白激酶（AMPK）信号通路促进巨噬细胞的M2极化。总之，纳米管修饰钛可以通过激活AMPK信号通路抑制巨噬细胞糖酵解，减少炎症因子释放，促进M2极化。在体外，内皮化被加速。我们的研究结果表明，钛纳米管可以作为一种潜在的方法，生物功能化钛基人工瓣膜内皮化。纳米管生物功能化钛可通过激活腺苷酸活化蛋白激酶（AMPK）信号通路，抑制巨噬细胞糖酵解，减少炎症因子释放，促进M2极化。在体外，内皮化被加速。我们的研究结果表明，钛纳米管可以作为一种潜在的方法，生物功能化钛基人工瓣膜内皮化
Titanium has been widely used in prosthetic valves, but they are associated with serious defects in titanium‐based prosthetic valves, such as thrombosis, calcification, and decay. Therefore, it is very important to biofunctionalize titanium‐based valves to reduce inflammation and accelerate endothelialization of stents and antithrombosis. The titanium dioxide nanotubes were prepared from pure titanium (Ti) by anodic oxidation method in this study. The effects of titanium dioxide nanotubes on the metabolism of macrophages and the inflammatory reaction as implants were studied in vitro. The polarization state of macrophages and the ability to accelerate endothelialization were analyzed. The results demonstrated that titanium nanotubes promote M2 polarization of macrophages by inhibiting glycolysis and activating the Adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway. In general, biofunctionalization titanium with nanotube could inhibit macrophage glycolysis, reduce inflammatory factor release and promote M2 polarization by activating the AMPK signaling pathway. And endothelialization was accelerated in vitro. Our result demonstrated that titanium nanotube could act as a potential approach to biofunctionlize titanium‐based prosthetic valves for endothelialization. Biofunctionalization titanium with nanotube could inhibit macrophage glycolysis, reduce inflammatory factor release and promote M2 polarization by activating the adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway. And endothelialization was accelerated in vitro. Our result demonstrated that titanium nanotube could act as a potential approach to biofunctionlize titanium‐based prosthetic valves for endothelialization
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影响因子：
5.8
作者：
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期刊：
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影响因子：
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DOI：
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影响因子：
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作者：
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