Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2.
Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2.
复制标题
DOI：
10.1016/j.antiviral.2022.105372
复制
发表时间：
2022-09
影响因子：
7.6
通讯作者：
中科院分区：
文献类型：
--
作者：
严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）Omicron亚变体BA.2已在许多国家传播，取代了早期的Omicron亚变体BA.1和其他变体。在这里，使用细胞培养感染试验，我们定量了BA.2和BA.1与其他相关变体α，γ和δ相比对五种批准的中和抗体和抗病毒药物的内在敏感性。我们的测定揭示了这些变体对抗体的不同敏感性，包括BA.1和BA.2对casirivimab以及BA.1对imdevimab的反应丧失。相比之下，EIDD-1931和Nirmatrelvir对这些变体显示出更保守的活性。结合数学分析的病毒应答特征估计了临床浓度变体之间的抗病毒作用差异。这些分析提供了重要的证据，使我们深入了解变异出现对选择最佳药物治疗的影响。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant BA.2 has spread in many countries, replacing the earlier Omicron subvariant BA.1 and other variants. Here, using a cell culture infection assay, we quantified the intrinsic sensitivity of BA.2 and BA.1 compared with other variants of concern, Alpha, Gamma, and Delta, to five approved-neutralizing antibodies and antiviral drugs. Our assay revealed the diverse sensitivities of these variants to antibodies, including the loss of response of both BA.1 and BA.2 to casirivimab and of BA.1 to imdevimab. In contrast, EIDD-1931 and nirmatrelvir showed a more conserved activities to these variants. The viral response profile combined with mathematical analysis estimated differences in antiviral effects among variants in the clinical concentrations. These analyses provide essential evidence that gives insight into variant emergence's impact on choosing optimal drug treatment.
登录
查看更多内容
DOI：
10.1126/science.abn8347
发表时间：
2022-03-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Elliott P;Bodinier B;Eales O;Wang H;Haw D;Elliott J;Whitaker M;Jonnerby J;Tang D;Walters CE;Atchison C;Diggle PJ;Page AJ;Trotter AJ;Ashby D;Barclay W;Taylor G;Ward H;Darzi A;Cooke GS;Chadeau-Hyam M;Donnelly CA
通讯作者：
Donnelly CA
影响因子：
64.5
作者：
Nutalai, Rungtiwa;Zhou, Daming;Tuekprakhon, Aekkachai;Ginn, Helen M.;Supasa, Piyada;Liu, Chang;Huo, Jiandong;Mentzer, Alexander J.;Duyvesteyn, Helen M. E.;Dijokaite-Guraliuc, Aiste;Skelly, Donal;Ritter, Thomas G.;Amini, Ali;Bibi, Sagida;Adele, Sandra;Johnson, Sile Ann;Constantinides, Bede;Webster, Hermione;Temperton, Nigel;Klenerman, Paul;Barnes, Eleanor;Dunachie, Susanna J.;Crook, Derrick;Pollard, Andrew J.;Lambe, Teresa;Goulder, Philip;Paterson, Neil G.;Williams, Mark A.;Hall, David R.;Mongkolsapaya, Juthathip;Fry, Elizabeth E.;Dejnirattisai, Wanwisa;Ren, Jingshan;Stuart, David, I;Screaton, Gavin R.
通讯作者：
Screaton, Gavin R.
影响因子：
82.9
作者：
VanBlargan LA;Errico JM;Halfmann PJ;Zost SJ;Crowe JE Jr;Purcell LA;Kawaoka Y;Corti D;Fremont DH;Diamond MS
通讯作者：
Diamond MS
影响因子：
64.8
作者：
Viana R;Moyo S;Amoako DG;Tegally H;Scheepers C;Althaus CL;Anyaneji UJ;Bester PA;Boni MF;Chand M;Choga WT;Colquhoun R;Davids M;Deforche K;Doolabh D;du Plessis L;Engelbrecht S;Everatt J;Giandhari J;Giovanetti M;Hardie D;Hill V;Hsiao NY;Iranzadeh A;Ismail A;Joseph C;Joseph R;Koopile L;Kosakovsky Pond SL;Kraemer MUG;Kuate-Lere L;Laguda-Akingba O;Lesetedi-Mafoko O;Lessells RJ;Lockman S;Lucaci AG;Maharaj A;Mahlangu B;Maponga T;Mahlakwane K;Makatini Z;Marais G;Maruapula D;Masupu K;Matshaba M;Mayaphi S;Mbhele N;Mbulawa MB;Mendes A;Mlisana K;Mnguni A;Mohale T;Moir M;Moruisi K;Mosepele M;Motsatsi G;Motswaledi MS;Mphoyakgosi T;Msomi N;Mwangi PN;Naidoo Y;Ntuli N;Nyaga M;Olubayo L;Pillay S;Radibe B;Ramphal Y;Ramphal U;San JE;Scott L;Shapiro R;Singh L;Smith-Lawrence P;Stevens W;Strydom A;Subramoney K;Tebeila N;Tshiabuila D;Tsui J;van Wyk S;Weaver S;Wibmer CK;Wilkinson E;Wolter N;Zarebski AE;Zuze B;Goedhals D;Preiser W;Treurnicht F;Venter M;Williamson C;Pybus OG;Bhiman J;Glass A;Martin DP;Rambaut A;Gaseitsiwe S;von Gottberg A;de Oliveira T
通讯作者：
de Oliveira T
影响因子：
64.8
作者：
Liu, Lihong;Iketani, Sho;Ho, David D.
通讯作者：
Ho, David D.