Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.
Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.
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DOI：
10.1016/j.ydbio.2021.02.003
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发表时间：
2021-05
影响因子：
2.7
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Vidaurre V;Chen X
配子发生是果蝇雄性和雌性种系中发生的最极端的细胞分化过程之一。这个过程始于生殖系干细胞，它经历不对称细胞分裂（ACD）以产生保留其干性的自我更新子细胞和经历表观遗传和基因组变化以最终产生单倍体配子的分化子细胞。分子遗传学和细胞生物学研究开始利用不断进步的基因组工具来了解：（1）生殖细胞如何能够在整个成年生殖寿命中保持其身份，以及（2）以平衡的方式进行分化。在这篇综述中，我们重点关注通过调节生殖细胞体通讯来解决这两个问题的表观遗传机制，以确保生殖干细胞的身份和活性。
Gametogenesis is one of the most extreme cellular differentiation processes that takes place in Drosophila male and female germlines. This process begins at the germline stem cell, which undergoes asymmetric cell division (ACD) to produce a self-renewed daughter that preserves its stemness and a differentiating daughter cell that undergoes epigenetic and genomic changes to eventually produce haploid gametes. Research in molecular genetics and cellular biology are beginning to take advantage of the continually advancing genomic tools to understand: (1) how germ cells are able to maintain their identity throughout the adult reproductive lifetime, and (2) undergo differentiation in a balanced manner. In this review, we focus on the epigenetic mechanisms that address these two questions through their regulation of germline-soma communication to ensure germline stem cell identity and activity.
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影响因子：
23.9
作者：
Ables, Elizabeth T.;Drummond-Barbosa, Daniela
通讯作者：
Drummond-Barbosa, Daniela
DOI：
10.1073/pnas.51.5.786
发表时间：
1964-01-01
影响因子：
11.1
作者：
ALLFREY, VG;FAULKNER, R;MIRSKY, AE
通讯作者：
MIRSKY, AE
影响因子：
56.9
作者：
Buszczak, Michael;Paterno, Shelley;Spradling, Allan C.
通讯作者：
Spradling, Allan C.
影响因子：
11.4
作者：
Ardehali, M. Behfar;Mei, Amanda;Kusch, Thomas
通讯作者：
Kusch, Thomas
影响因子：
2.7
作者：
Akiyama, Takuya;Kamimura, Keisuke;Nakato, Hiroshi
通讯作者：
Nakato, Hiroshi