The public health exposome: a population-based, exposure science approach to health disparities research.
The public health exposome: a population-based, exposure science approach to health disparities research.
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DOI：
10.3390/ijerph111212866
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发表时间：
2014-12
影响因子：
--
通讯作者：
Lichtveld MY
中科院分区：
文献类型：
--
作者：
Juarez PD;Matthews-Juarez P;Hood DB;Im W;Levine RS;Kilbourne BJ;Langston MA;Al-Hamdan MZ;Crosson WL;Estes MG;Estes SM;Agboto VK;Robinson P;Wilson S;Lichtveld MY
在缩小健康差距方面缺乏进展表明，如果我们要实现有意义、公平和持久的减少，就需要采取新的方法。目前的科学范式没有充分反映环境、个人健康和人口水平差异之间关系的复杂性。公共卫生暴露组是一个通用的暴露跟踪框架，用于在从受孕到死亡的整个生命周期内整合外源性和内源性暴露之间的复杂关系。它使用了一个建立在曝光组范式之上的社会生态框架，用来概念化外源性暴露是如何“深入皮肤”的。公共卫生暴露方法使我们的团队开发了一个分类和生物信息学基础设施，以将健康结果数据与数千个外源性暴露来源整合在四个大的领域：自然、建筑、社会和政策环境。在一个跨学科团队的投入下，我们借用和应用了不同学科的方法、工具和术语来衡量环境暴露对个人和人群健康结果和差异的影响，其中许多影响可能要到多年后才会显现。作为范式转换的惯例，这种方法对研究方法和设计、分析、社区参与战略和研究培训具有深远的影响。
The lack of progress in reducing health disparities suggests that new approaches are needed if we are to achieve meaningful, equitable, and lasting reductions. Current scientific paradigms do not adequately capture the complexity of the relationships between environment, personal health and population level disparities. The public health exposome is presented as a universal exposure tracking framework for integrating complex relationships between exogenous and endogenous exposures across the lifespan from conception to death. It uses a social-ecological framework that builds on the exposome paradigm for conceptualizing how exogenous exposures “get under the skin”. The public health exposome approach has led our team to develop a taxonomy and bioinformatics infrastructure to integrate health outcomes data with thousands of sources of exogenous exposure, organized in four broad domains: natural, built, social, and policy environments. With the input of a transdisciplinary team, we have borrowed and applied the methods, tools and terms from various disciplines to measure the effects of environmental exposures on personal and population health outcomes and disparities, many of which may not manifest until many years later. As is customary with a paradigm shift, this approach has far reaching implications for research methods and design, analytics, community engagement strategies, and research training.
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影响因子：
10.4
作者：
Birnbaum LS;Bucher JR;Collman GW;Zeldin DC;Johnson AF;Schug TT;Heindel JJ
通讯作者：
Heindel JJ
DOI：
10.1111/j.1467-8306.1995.tb01818.x
发表时间：
1995-12-01
期刊：
ANNALS OF THE ASSOCIATION OF AMERICAN GEOGRAPHERS
影响因子：
--
作者：
Bowen, WM;Salling, MJ;Cyran, EJ
通讯作者：
Cyran, EJ
影响因子：
3.3
作者：
Carroll JE;Diez Roux AV;Fitzpatrick AL;Seeman T
通讯作者：
Seeman T
影响因子：
1.9
作者：
BULLARD, RD
通讯作者：
BULLARD, RD
影响因子：
8.7
作者：
Anderson, Candace;Beazley, Karen;Boxall, James
通讯作者：
Boxall, James