Acupuncture for Managing Cancer-Related Insomnia: A Systematic Review of Randomized Clinical Trials.

Acupuncture for Managing Cancer-Related Insomnia: A Systematic Review of Randomized Clinical Trials.
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DOI:
10.1177/1534735416664172
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发表时间:
2017-06
影响因子:
2.9
通讯作者:
Lee MS
Lee MS
中科院分区:
医学3区
文献类型:
--
作者:
Choi TY;Kim JI;Lim HJ;Lee MS

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背景失眠是癌症患者的一个突出症状,可以显着影响他们的生活质量和与睡眠质量相关的症状。传统的药物方法在缓解失眠症患者方面的成功率很低。本系统回顾的目的是评估针灸治疗癌症相关失眠的疗效。方法.从开始到2016年1月共检索了12个数据库,无语言限制。随机对照试验(RCTs)和准RCTs,如果针灸被用作唯一的干预或作为任何癌症相关失眠的另一种标准治疗的辅助。数据提取和偏倚风险评估由2名独立审查员进行。结果在筛选的90项研究中,纳入了6项RCT。偏倚风险通常不明确或较低。3项RCT对匹兹堡睡眠质量指数的影响相当,2项RCT对治疗结束时的有效率的影响与常规药物相似。另一项随机对照试验显示,针灸在每晚睡眠时间和每晚醒来次数方面优于激素治疗。2项随机对照试验的3周随访结果显示,针刺治疗效果上级常规药物治疗,荟萃分析显示针刺治疗效果显著。两项随机对照试验测试了针灸与假针灸相比对癌症相关失眠的影响。一项随机对照试验显示了有利的效果,而另一项试验则未能做到这一点。结论有一个低水平的证据表明,针灸可能优于假针灸,药物或激素治疗上级。然而,临床意义的研究数量和效应量都很小。进一步的临床试验是必要的。
Background. Insomnia is a prominent complaint of cancer patients that can significantly affect their quality of life and symptoms related to sleep quality. Conventional drug approaches have a low rate of success in alleviating those suffering insomnia. The aim of this systematic review was to assess the efficacy of acupuncture in the management of cancer-related insomnia. Methods. A total of 12 databases were searched from their inception through January 2016 without language restriction. Randomized controlled trials (RCTs) and quasi-RCTs were included if acupuncture was used as the sole intervention or as an adjunct to another standard treatment for any cancer-related insomnia. The data extraction and the risk of bias assessments were performed by 2 independent reviewers. Results. Of the 90 studies screened, 6 RCTs were included. The risk of bias was generally unclear or low. Three RCTs showed equivalent effects on the Pittsburgh Sleep Quality Index and 2 RCTs showed the similar effects on response rate to those of conventional drugs at the end of treatment. The other RCT showed acupuncture was better than hormone therapy in the numbers of hours slept each night and number of times woken up each night. The 3 weeks of follow-up in 2 RCTs showed superior effects of acupuncture compared with conventional drugs, and a meta-analysis showed significant effects of acupuncture. Two RCTs tested the effects of acupuncture on cancer-related insomnia compared with sham acupuncture. One RCT showed favourable effects, while the other trial failed to do so. Conclusion. There is a low level of evidence that acupuncture may be superior to sham acupuncture, drugs or hormones therapy. However, the number of studies and effect size are small for clinical significance. Further clinical trials are warranted.
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