Distinct stress-related medial prefrontal cortex activation in women with depression with and without childhood maltreatment.
Distinct stress-related medial prefrontal cortex activation in women with depression with and without childhood maltreatment.
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DOI：
10.1002/da.23243
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发表时间：
2022-04
影响因子：
7.4
通讯作者：
Pizzagalli, Diego A.
中科院分区：
文献类型：
--
作者：
Dong, Daifeng;Belleau, Emily L.;Ironside, Maria;Zhong, Xue;Sun, Xiaoqiang;Xiong, Ge;Cheng, Chang;Li, Chuting;Wang, Xiang;Yao, Shuqiao;Pizzagalli, Diego A.
新出现的证据强调了儿童期虐待（CM）在形成重度抑郁症（MDD）神经生物学异常中的调节作用。然而，是否神经机制的压力敏感性在抑郁症的影响，儿童虐待的历史尚不清楚。招募了213名无药物治疗的女性参与者进行功能性磁共振成像研究，评估心理社会压力对神经反应的影响。对44名女性MDD伴CM患者（MDD/CM）、32名女性MDD不伴CM患者（MDD/noCM）、43名女性健康对照（HC）伴CM患者（HC/CM）和94名女性HC不伴CM患者（HC/noCM）进行蒙特利尔影像应激任务。进行CM（CM，noCM）×诊断（MDD，HC）全脑体素分析，以评估神经应激反应的推定组差异。在内侧前额叶皮层（mPFC）中出现了显著的CM ×诊断交互作用。Bonferroni校正的简单效应分析阐明，（1）MDD/CM组的mPFC失活少于HC/CM组，（2）MDD/noCM组的mPFC失活大于HC/noCM组，（3）MDD/CM组的mPFC失活少于MDD/noCM组。此外，mPFC种子心理生理相互作用分析显示，相对于noCM组，CM组中的个体具有显著更大的压力相关mPFC-左额上上级回和mPFC-右后小脑连接。研究结果突出了不同的神经异常MDD取决于以前的CM的历史，特别是增强压力相关的mPFC招聘MDD个人报告CM。此外，CM病史通常与以mPFC为中心的功能连接中断相关。
Emerging evidence has highlighted the moderating effect of childhood maltreatment (CM) in shaping neurobiological abnormalities in major depressive disorder (MDD). However, whether neural mechanisms underlying stress sensitivity in MDD are affected by history of childhood maltreatment is unclear. 213 medication-free female participants were recruited for a functional magnetic resonance imaging study assessing the effects of psychosocial stress on neural responses. The Montreal Imaging Stress Task was administrated to 44 female MDD patients with CM (MDD/CM), 32 female MDD patients without CM (MDD/noCM), 43 female healthy controls (HCs) with CM (HC/CM), and 94 female HCs without CM (HC/noCM). A CM (CM, noCM) × Diagnosis (MDD, HC) whole-brain voxel-wise analysis was run to assess putative group differences in neural stress responses. A significant CM × Diagnosis interaction emerged in the medial prefrontal cortex (mPFC). Bonferroni-corrected simple effects analysis clarified that (1) the MDD/CM group had less mPFC deactivation than the HC/CM group, (2) the MDD/noCM group exhibited greater mPFC deactivation than the HC/noCM group, and (3) the MDD/CM group exhibited less mPFC deactivation relative to the MDD/noCM group. In addition, the mPFC-seed psychophysiological interaction analysis revealed that individuals in the CM groups had significantly greater stress-related mPFC-left superior frontal gyrus and mPFC-right posterior cerebellum connectivity relative to the noCM groups. Findings highlight distinct neural abnormalities in MDD depending on prior CM history, particularly potentiated stress-related mPFC recruitment among MDD individuals reporting CM. Moreover, CM history was generally associated with disruption in functional connectivity centered on the mPFC.
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DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
4.7
作者：
Cassiers LLM;Sabbe BGC;Schmaal L;Veltman DJ;Penninx BWJH;Van Den Eede F
通讯作者：
Van Den Eede F
影响因子：
6.9
作者：
Jenness JL;Peverill M;Miller AB;Heleniak C;Robertson MM;Sambrook KA;Sheridan MA;McLaughlin KA
通讯作者：
McLaughlin KA
影响因子：
2.9
作者：
Hart H;Rubia K
通讯作者：
Rubia K
影响因子：
5
作者：
Callaghan BL;Tottenham N
通讯作者：
Tottenham N