Crosstalk of carcinoembryonic antigen and transforming growth factor-β via their receptors: comparing human and canine cancer.
Crosstalk of carcinoembryonic antigen and transforming growth factor-β via their receptors: comparing human and canine cancer.
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DOI：
10.1007/s00262-015-1684-6
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发表时间：
2015-05
影响因子：
5.8
通讯作者：
Tanaka, Akane
中科院分区：
文献类型：
--
作者：
Jensen-Jarolim, Erika;Fazekas, Judit;Singer, Josef;Hofstetter, Gerlinde;Oida, Kumiko;Matsuda, Hiroshi;Tanaka, Akane
关键词：
越来越多的证据表明，转化生长因子β（TGF-β）和核因子κ-B（NFκB）通路紧密相连，在肿瘤的恶性转化中发挥关键作用。调节性T淋巴细胞和B淋巴细胞（Tlymphocyte，Blymphocyte）的免疫浸润最近因其是TGF-β的重要来源而受到越来越多的关注。关于癌胚抗原（CEA）的促肿瘤发生功能的研究很多，但对其受体CEAR的研究却少得多。到目前为止，有一个单一的连接报告，TGF-β也可能通过CEAR信号。癌组织之间的相互作用由于CEAR和TGF-β受体在基质细胞中的表达以及TGF-β在上皮-间充质转化中的作用而进一步复杂化。此外，肿瘤浸润性TGF-β和Bcl-2可通过分泌TGF-β与癌细胞的CEAR结合来直接指导癌细胞。因此，TGF-β和CEA可能在乳腺癌中协同作用并导致疾病进展，NFκB可能是它们信号传导的共同交叉点。CEAR、TGF-β1-3、TGF-β-R I-III型和NFκB B I和II类分子具有突出的人-犬序列同一性，只有犬CEA同源物尚未鉴定。由于这些原因，狗可能是用于研究相互连接的CEA和TGF-β网络的串扰的有效平移模型患者。
There is accumulating evidence that the transforming growth factor beta (TGF-β) and nuclear factor kappa-B (NFκB) pathways are tightly connected and play a key role in malignant transformation in cancer. Immune infiltration by regulatory T- and B-lymphocytes (Tregs, Bregs) has recently gained increased attention for being an important source of TGF-β. There is a plethora of studies examining the pro-tumorigenic functions of carcinoembryonic antigen (CEA), but its receptor CEAR is far less studied. So far, there is a single connecting report that TGF-β also may signal through CEAR. The crosstalk between cancer tissues is further complicated by the expression of CEAR and TGF-β receptors in stromal cells, and implications of TGF-β in epithelial–mesenchymal transition. Furthermore, tumor-infiltrating Tregs and Bregs may directly instruct cancer cells by secreting TGF-β binding to their CEAR. Therefore, both TGF-β and CEA may act synergistically in breast cancer and cause disease progression, and NFκB could be a common crossing point between their signaling. CEAR, TGF-β1–3, TGF-β-R types I–III and NFκB class I and II molecules have an outstanding human–canine sequence identity, and only a canine CEA homolog has not yet been identified. For these reasons, the dog may be a valid translational model patient for investigating the crosstalk of the interconnected CEA and TGF-β networks.
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DOI：
10.4137/cgm.s14205
发表时间：
2014
期刊：
Cancer growth and metastasis
影响因子：
--
作者：
Gupta DK;Singh N;Sahu DK
通讯作者：
Sahu DK
影响因子：
32.4
作者：
Chen L;Chen Z;Baker K;Halvorsen EM;da Cunha AP;Flak MB;Gerber G;Huang YH;Hosomi S;Arthur JC;Dery KJ;Nagaishi T;Beauchemin N;Holmes KV;Ho JW;Shively JE;Jobin C;Onderdonk AB;Bry L;Weiner HL;Higgins DE;Blumberg RS
通讯作者：
Blumberg RS
DOI：
10.1007/978-1-4939-1161-5_19
发表时间：
2014
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.8
作者：
Bajenova, OV;Zimmer, R;Thomas, P
通讯作者：
Thomas, P
影响因子：
2.6
作者：
Egenvall, A;Bonnett, BN;von Euler, H
通讯作者：
von Euler, H