A multiscale biomechanical model of platelets: Correlating with in-vitro results.
A multiscale biomechanical model of platelets: Correlating with in-vitro results.
复制标题
血小板的多尺度生物力学模型：与体外结果相关。
DOI：
10.1016/j.jbiomech.2016.11.019
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发表时间：
2017
影响因子：
2.4
通讯作者：
Bluestein,Danny
中科院分区：
文献类型：
--
作者：
Zhang,Peng;Zhang,Li;Slepian,MarvinJ;Deng,Yuefan;Bluestein,Danny
利用耗散粒子动力学（DPD）结合粗粒分子动力学（CGMD）方法，建立了一个多尺度可变形血小板模型，以精确描述血小板内分子尺度的成分和血液流动中血小板的生物力学性质.我们的模型包括血小板双层膜，细胞质和一个精心设计的弹性细胞骨架。将数值模拟与已发表的体外实验相关联，我们验证了细胞质的生物流变学，膜对外部应力的弹性响应，以及细胞骨架肌动蛋白丝的刚度，从而准确表示血小板的分子水平生物力学微观结构。这使我们能够研究血液动力学应力作用于血小板膜并传递到这些细胞内成分的机械转导过程。薄片组分响应于流动引起的应力而连续变形。据我们所知，这是第一个分子级血小板模型，可用于准确预测导致人工心血管器械和血管疾病过程中血栓形成的血小板活化机制。该模型可进一步用于研究通过机械转导途径调节血小板特性以增强其剪切阻力的新治疗方法的效果。
Using dissipative particle dynamics (DPD) combined with coarse grained molecular dynamics (CGMD) approaches, we developed a multiscale deformable platelet model to accurately describe the molecular-scale intra-platelet constituents and biomechanical properties of platelets in blood flow. Our model includes the platelet bilayer membrane, cytoplasm and an elaborate elastic cytoskeleton. Correlating numerical simulations with published in-vitro experiments, we validated the biorheology of the cytoplasm, the elastic response of membrane to external stresses, and the stiffness of the cytoskeleton actin filaments, resulting in an accurate representation of the molecular-level biomechanical microstructures of platelets. This enabled us to study the mechanotransduction process of the hemodynamic stresses acting onto the platelet membrane and transmitted to these intracellular constituents. The platelets constituents continuously deform in response to the flow induced stresses. To the best of our knowledge, this is the first molecular-scale platelet model that can be used to accurately predict platelets activation mechanism leading to thrombus formation in prosthetic cardiovascular devices and in vascular disease processes. This model can be further employed to study the effects of novel therapeutic approaches of modulating platelet properties to enhance their shear resistance via mechanotransduction pathways.
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影响因子：
4.1
作者：
Nien-Tzu Wang;A. Fogelson
通讯作者：
Nien-Tzu Wang;A. Fogelson
影响因子：
3.8
作者：
Yamaguchi, Takami;Ishikawa, Takuji;Imai, Y.;Matsuki, N.;Xenos, Mikhail;Deng, Yuefan;Bluestein, Danny
通讯作者：
Bluestein, Danny
独立的止血机制：剪切诱导血小板聚集。
影响因子：
--
作者：
J. O'brien;G. Salmon
通讯作者：
G. Salmon
影响因子：
3.4
作者：
Fedosov, Dmitry A.;Caswell, Bruce;Karniadakis, George Em
通讯作者：
Karniadakis, George Em
DOI：
10.1073/pnas.91.26.12962
发表时间：
1994-12-20
影响因子：
11.1
作者：
KOJIMA, H;ISHIJIMA, A;YANAGIDA, T
通讯作者：
YANAGIDA, T