Relationship between late-life hypertension, blood pressure, and Alzheimer's disease.
Relationship between late-life hypertension, blood pressure, and Alzheimer's disease.
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DOI：
10.1177/1533317511421779
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Morris JC
中科院分区：
文献类型：
--
作者：
Yang YH;Roe CM;Morris JC
晚年高血压与 AD 之间的关系尚不清楚。采用横断面和纵向方法来检查晚年的收缩压（SBP）、舒张压（DBP）、脉压（PP）、平均动脉压（MAP）和自报高血压（S-HTN）是否与患有和发展 AD 相关。在横断面检查中，有 1,768 名 AD 患者和 818 名非痴呆患者，AD 与 S-HTN 或任何血压测量值均无显着相关性（S-HTN：p=0.236；SBP：p=0.095；DBP：p=0.429；PP：p=0.145；MAP：p=0.162）。在纵向检查中，纳入了 594 名非痴呆个体，其中 171 名在入组时自我报告患有高血压，423 名没有患有高血压。 DBP 与 AD 的发生显着相关 (p=0.030)，但与 S-HTN (p=0.251)、SBP (p=0.294)、PP (p=0.919) 和 MAP (p=0.060) 无关。该协会强调有必要进行进一步研究，以概述晚年 DBP 与后期 AD 的详细机制和生物学相关性（如果有的话）。
Relationships between late-life hypertension and AD remain less clear. Both cross-sectional and longitudinal methods were used to examine whether systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), and self-reported hypertension (S-HTN) in late life were associated with having and developing AD. In the cross-sectional examination were 1,768 individuals with AD and 818 nondemented individual, and AD was not significantly associated with S-HTN or any of blood pressure measures (S-HTN: p=0.236; SBP: p=0.095; DBP: p=0.429; PP: p=0.145; MAP: p=0.162). In the longitudinal examination, 594 nondemented individuals, 171 with and 423 without self-reported hypertension at entry, were included. DBP was significantly related to the development of AD (p=0.030), but not S-HTN (p=0.251), SBP (p=0.294) PP (p=0.919), and MAP (p=0.060). The association underscores the necessity of further investigation to outline the detailed mechanisms and biological relevance, if any, of late-life DBP to later AD.
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