Platelet reactivity and platelet count in women with iron deficiency treated with intravenous iron.
Platelet reactivity and platelet count in women with iron deficiency treated with intravenous iron.
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DOI：
10.1002/rth2.12692
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发表时间：
2022-03
影响因子：
4.6
通讯作者：
Shatzel JJ
中科院分区：
文献类型：
--
作者：
Elstrott BK;Lakshmanan HHS;Melrose AR;Jordan KR;Martens KL;Yang CJ;Peterson DF;McMurry HS;Lavasseur C;Lo JO;Olson SR;DeLoughery TG;Aslan JE;Shatzel JJ
缺铁性贫血(IDA)和月经大出血是普遍存在的相互关联的问题，影响着全球3亿多绝经前妇女。IDA通常与血小板计数增加有关；然而，IDA及其对绝经前妇女血小板功能的校正的影响仍不清楚。我们试图确定IDA和静脉补铁如何影响绝经前妇女的血小板计数和血小板功能。血液学指标在231名接受静脉补铁的多中心回溯性队列中进行了评估。然后从13名女性的前瞻性队列中采集输液前和输注后的血样，用生理切变下的流式细胞仪和血小板聚集性分析来分析静脉补铁对血液学参数和血小板功能的影响。在铁替代治疗后，在回顾和前瞻性队列中，贫血得到改善，平均血小板计数分别下降了26.5和16.0 kK/mm3。置换降低了基线的血小板表面P-选择素水平，同时增强了对包括胶原相关肽和ADP在内的激动剂的血小板分泌反应。生理剪切力下的血小板在胶原上的粘附性和聚集性在充血后也显著增加。我们发现，静脉注射铁改善了绝经前缺铁妇女的贫血，同时恢复了血小板计数和血小板分泌反应。我们的结果表明，缺铁和铁替代会对血小板的产生和功能产生一系列影响。因此，应该进一步检查患有IDA的妇女和其他人群的血小板反应性情况，在这些人群中，替代治疗提供了一种改善贫血和生活质量的有希望的方法。
Iron deficiency anemia (IDA) and heavy menstrual bleeding are prevalent, interrelated issues impacting over 300 million premenopausal women worldwide. IDA is generally associated with increased platelet counts; however, the effects of IDA and its correction on platelet function in premenopausal women remain unknown. We sought to determine how IDA and intravenous iron affect platelet count and platelet function in premenopausal women. Hematologic indices were assessed in a multicenter, retrospective cohort of 231 women repleted with intravenous iron. Pre‐ and postinfusion blood samples were then obtained from a prospective cohort of 13 women to analyze the effect of intravenous iron on hematologic parameters as well as platelet function with flow cytometry and platelet aggregation assays under physiologic shear. Following iron replacement, anemia improved, and mean platelet counts decreased by 26.5 and 16.0 K/mm3 in the retrospective and prospective cohorts, respectively. Replacement reduced baseline platelet surface P‐selectin levels while enhancing platelet secretory responses to agonists, including collagen‐related peptide and ADP. Platelet adhesion and aggregation on collagen under physiologic shear also significantly increased following repletion. We find that intravenous iron improves anemia while restoring platelet counts and platelet secretory responses in premenopausal women with iron deficiency. Our results suggest that iron deficiency as well as iron replacement can have a range of effects on platelet production and function. Consequently, platelet reactivity profiles should be further examined in women and other groups with IDA where replacement offers a promising means to improve anemia as well as quality of life.
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影响因子：
3.9
作者：
IULIANO, L;VIOLI, F;BALSANO, F
通讯作者：
BALSANO, F
影响因子：
5.9
作者：
PARETI, FI;CAPITANIO, A;MANNUCCI, PM
通讯作者：
MANNUCCI, PM
Toll样受体2配体PAM2CSK4激活血小板核因子-XB和Bruton的酪氨酸激酶信号传导，以促进血小板 - 内皮细胞相互作用。
影响因子：
7.3
作者：
Parra-Izquierdo I;Lakshmanan HHS;Melrose AR;Pang J;Zheng TJ;Jordan KR;Reitsma SE;McCarty OJT;Aslan JE
通讯作者：
Aslan JE
DOI：
10.1161/atvbaha.120.314647
发表时间：
2021-03
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Aslan JE
通讯作者：
Aslan JE
影响因子：
3.7
作者：
Kulnigg-Dabsch, Stefanie;Evstatiev, Rayko;Gasche, Christoph
通讯作者：
Gasche, Christoph