3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus.
3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus.
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DOI：
10.1155/2012/946867
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kuwata K
中科院分区：
文献类型：
--
作者：
Takemura T;Urushisaki T;Fukuoka M;Hosokawa-Muto J;Hata T;Okuda Y;Hori S;Tazawa S;Araki Y;Kuwata K
巴西绿蜂胶水提取物(PWE)及其化学成分咖啡酰奎宁酸，如3，4-二咖啡酰奎宁酸(3，4-diCQA)，可在不影响病毒成分的情况下抗甲型流感病毒(IAV)。在此，我们评价了这些化合物的体内抗IAV活性。用巴西绿蜂胶乙醇提取物(Pre)或巴西绿蜂胶乙醇提取物(PEE)按2 0 0 mg/kg剂量灌胃接种A/WSN/33毒株的Balb/c小鼠。与未处理的小鼠相比，经PWE处理的小鼠的寿命显著延长。3，4-二氯喹啉50 mg/kg灌胃给药的作用强于丹参提取物本身。我们发现，与对照组相比，给予3，4-diCQA的小鼠肿瘤坏死因子相关的凋亡诱导配体(TRAIL)mRNA的量显著增加，而H1N1血凝素(HA)的mRNA略有下降。这些数据表明，PWE、PEE或3，4-diCQA具有一种新颖而独特的抗流感病毒活性机制，即通过增加TRAIL来促进病毒清除。
Brazilian green propolis water extract (PWE) and its chemical components, caffeoylquinic acids, such as 3,4-dicaffeoylquinic acid (3,4-diCQA), act against the influenza A virus (IAV) without influencing the viral components. Here, we evaluated the anti-IAV activities of these compounds in vivo. PWE or PEE (Brazilian green propolis ethanol extract) at a dose of 200 mg/kg was orally administered to Balb/c mice that had been inoculated with IAV strain A/WSN/33. The lifetimes of the PWE-treated mice were significantly extended compared to the untreated mice. Moreover, oral administration of 3,4-diCQA, a constituent of PWE, at a dose of 50 mg/kg had a stronger effect than PWE itself. We found that the amount of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA in the mice that were administered 3,4-diCQA was significantly increased compared to the control group, while H1N1 hemagglutinin (HA) mRNA was slightly decreased. These data indicate that PWE, PEE or 3,4-diCQA possesses a novel and unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.
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DOI：
10.1093/ecam/neh034
发表时间：
2004-09-01
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chen CN;Weng MS;Wu CL;Lin JK
通讯作者：
Lin JK
影响因子：
3.8
作者：
Markham, KR;Mitchell, KA;Lu, YR
通讯作者：
Lu, YR
影响因子：
1.8
作者：
Drago, L;Mombelli, B;Gismondo, MR
通讯作者：
Gismondo, MR
影响因子：
2
作者：
Izuta, Hiroshi;Narahara, Yukimi;Hara, Hideaki
通讯作者：
Hara, Hideaki
影响因子：
3.7
作者：
Aggarwal S;Bradel-Tretheway B;Takimoto T;Dewhurst S;Kim B
通讯作者：
Kim B