Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers.
Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers.
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四个星期的短链果糖摄入摄入导致健康的老年志愿者的粪便双歧杆菌和胆固醇排泄增加。
DOI：
10.1186/1475-2891-6-42
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发表时间：
2007-12-05
影响因子：
5.4
通讯作者：
Bornet F
中科院分区：
文献类型：
--
作者：
Bouhnik Y;Achour L;Paineau D;Riottot M;Attar A;Bornet F
短链低聚果糖（scFOS）因其益生元特性而越来越多地用于人类饮食中。我们的目的是调查scFOS摄入对老年健康人结肠菌群和口粪转运时间的影响。在12名年龄为69 ± 2岁的健康志愿者中，在三个连续的阶段中评估粪便组成、口-粪转运时间和临床耐受性：基础期（2周）、scFOS（Actilight®）摄入期（8 g/d，持续4周）和随访期（4周）。以时间和治疗为因素的双因素方差分析用于比较三个时期之间的主要结局指标。在scFOS期间，粪便中的双歧杆菌计数显著增加（9.17 ± 0.17 log cfu/g vs基础期的8.52 ± 0.26 log cfu/g），并在随访结束时恢复到其初始值（8.37 ± 0.21 log cfu/g; P < 0.05）。粪便胆固醇浓度在scFOS期间增加（8.18 ± 2.37 mg/g干物质vs基础期的2.81 ± 0.94 mg/g干物质），并在随访结束时恢复至基线值（2.87 ± 0.44 mg/g干物质; P < 0.05）。与基础期相比，在scFOS摄入期间和随访期间粪便pH趋于降低（P = 0.06）。在整个研究过程中，粪便胆汁酸、粪便重量、含水率和口粪转运时间没有变化。与基础期相比，在scFOS摄入期间，过量的肠胃气胀和腹胀显著更频繁（P < 0.05），但这些症状的强度非常轻微。四周8 g/d scFOS摄入耐受性良好，并导致健康老年受试者的粪便双歧杆菌显著增加。胆固醇代谢的改变是否能发挥有益的作用还有待进一步研究。
Short-chain fructo-oligosaccharides (scFOS) are increasingly used in human diet for their prebiotic properties. We aimed at investigating the effects of scFOS ingestion on the colonic microflora and oro-fecal transit time in elderly healthy humans. Stools composition, oro-fecal transit time, and clinical tolerance were evaluated in 12 healthy volunteers, aged 69 ± 2 yrs, in three consecutive periods: basal period (2 weeks), scFOS (Actilight®) ingestion period (8 g/d for 4 weeks) and follow-up period (4 weeks). Two-way ANOVA, with time and treatment as factors, was used to compare the main outcome measures between the three periods. Fecal bifidobacteria counts were significantly increased during the scFOS period (9.17 ± 0.17 log cfu/g vs 8.52 ± 0.26 log cfu/g during the basal period) and returned to their initial values at the end of follow-up (8.37 ± 0.21 log cfu/g; P < 0.05). Fecal cholesterol concentration increased during the scFOS period (8.18 ± 2.37 mg/g dry matter vs 2.81 ± 0.94 mg/g dry matter during the basal period) and returned to the baseline value at the end of follow-up (2.87 ± 0.44 mg/g dry matter; P < 0.05). Fecal pH tended to decrease during scFOS ingestion and follow-up periods compared to the basal period (P = 0.06). Fecal bile acids, stool weight, water percentage, and oro-fecal transit time did not change throughout the study. Excess flatus and bloating were significantly more frequent during scFOS ingestion when compared to the basal period (P < 0.05), but the intensity of these symptoms was very mild. Four-week 8 g/d scFOS ingestion is well tolerated and leads to a significant increase in fecal bifidobacteria in healthy elderly subjects. Whether the change in cholesterol metabolism found in our study could exert a beneficial action warrants further studies.
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影响因子：
9.7
作者：
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通讯作者：
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影响因子：
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