Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study.
Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study.
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治疗阿尔茨海默氏病中阻塞性睡眠呼吸暂停的认知作用：一项随机对照研究。
DOI：
10.1111/j.1532-5415.2008.01934.x
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发表时间：
2008-11
影响因子：
6.3
通讯作者：
Loredo JS
中科院分区：
文献类型：
--
作者：
Ancoli-Israel S;Palmer BW;Cooke JR;Corey-Bloom J;Fiorentino L;Natarajan L;Liu L;Ayalon L;He F;Loredo JS
研究持续气道正压通气（CPAP）治疗阿尔茨海默病（AD）患者阻塞性睡眠呼吸暂停（OSA）是否会改善认知功能。随机双盲安慰剂对照试验。参与者被随机分配到治疗性CPAP治疗6周或安慰剂CPAP治疗3周，然后治疗性CPAP治疗3周。一般临床研究中心52名患有轻度-中度AD和OSA的男性和女性患者在治疗前、治疗3周和6周时进行持续气道正压通气。比较随机接受3周治疗性CPAP与安慰剂CPAP的受试者，发现认知没有显著改善。治疗性CPAP治疗3周后，两组治疗前与治疗后神经心理学测试评分的比较显示，认知功能有显著改善。这项研究的动力不足，无法对特定认知结构的改善做出明确的陈述。然而，探索性事后检查的变化分数的个人测试表明，改善情节口头学习和记忆和执行功能的某些方面，如认知灵活性，和心理处理速度。OSA可加重痴呆患者的认知功能障碍，因此可能是AD患者认知功能丧失的可逆原因。阻塞性睡眠呼吸暂停综合症治疗似乎可以改善一些认知功能。当存在OSA时，护理AD患者的临床医生应考虑实施CPAP治疗。
To examine whether treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) in patients with Alzheimer's disease (AD) would result in improved cognitive function. Randomized double-blind placebo-controlled trial. Participants were randomized to either therapeutic CPAP for six weeks or placebo CPAP for three weeks followed by therapeutic CPAP for three weeks. General clinical research center 52 men and women with mild-moderate AD and OSA Continuous positive airway pressure A complete neuropsychological test battery was administered before treatment, at three and at six-weeks. A comparison of subjects randomized to 3 weeks of therapeutic versus placebo CPAP suggested no significant improvements in cognition. A comparison of pre- versus post-treatment neuropsychological test scores after 3 weeks of therapeutic CPAP in both groups showed a significant improvement in cognition. The study was underpowered to make definitive statements about improvements within specific cognitive constructs. However, exploratory post-hoc examination of change scores for individual tests suggested improvements in episodic verbal learning and memory and some aspects of executive functioning such as cognitive flexibility, and mental processing speed. OSA may aggravate cognitive dysfunction in dementia and thus may be a reversible cause of cognitive loss in AD patients. OSA treatment seems to improve some of the cognitive functioning. Clinicians who care for AD patients should consider implementing CPAP treatment when OSA is present.
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影响因子：
4.4
作者：
Kotterba, S;Rasche, K;Malin, JP
通讯作者：
Malin, JP
影响因子：
2.5
作者：
Alchanatis, Manos;Zias, Nikolaos;Roussos, Charis
通讯作者：
Roussos, Charis
影响因子：
3.9
作者：
Benedict, RHB;Schretlen, D;Brandt, J
通讯作者：
Brandt, J
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM
影响因子：
168.9
作者：
Farré, R;Hernández, L;Navajas, D
通讯作者：
Navajas, D