Inactivation of the thalamic paraventricular nucleus promotes place preference and sucrose seeking in male rats.
Inactivation of the thalamic paraventricular nucleus promotes place preference and sucrose seeking in male rats.
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DOI：
10.1007/s00213-022-06160-2
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发表时间：
2022-08
影响因子：
3.4
通讯作者：
Barson, Jessica R.
中科院分区：
文献类型：
--
作者：
Gargiulo, Andrew T.;Badve, Preeti S.;Curtis, Genevieve R.;Prino, Breanne E.;Barson, Jessica R.
关键词：
奖励的体验包含积极的情感和动机。虽然负责奖励的这些不同方面的大脑区域彼此分离，但丘脑室旁核（PVT）可能在两者中发挥作用。研究PVT在情感和动机中的作用，并鉴定可能介导这些作用的神经肽。在用GABAB和GABAA激动剂巴氯芬+蝇蕈醇局部注射暂时灭活前部或后部PVT后，测试雄性大鼠的条件性位置偏爱。在固定比率3（FR 3）强化方案下和消退后，在巴氯芬+蝇蕈醇或盐水媒介物注射到后PVT中后，测试它们的蔗糖寻求。最后，使用定量实时PCR来检查在巴氯芬+蝇蕈醇或生理盐水载体注射到后PVT中后的局部神经肽基因表达。条件性位置偏爱诱导暂时失活的后部，但不是前部的PVT。而蔗糖寻求下的FR3时间表的强化不受失活的后部PVT，恢复蔗糖寻求促进后部PVT失活。垂体腺苷酸环化酶激活多肽（PACAP），但不是脑啡肽或神经降压素的局部基因表达，减少后PVT.Temporary失活的后PVT影响的影响和动机，以及局部基因表达的PACAP。这些结果表明，后PVT是一个大脑区域，可能参与奖励的两个主要方面。
The experience of reward entails both positive affect and motivation. While the brain regions responsible for these distinct aspects of reward are dissociable from each other, the paraventricular nucleus of the thalamus (PVT) may play a role in both. To investigate the role of the PVT in both affect and motivation, and to identify neuropeptides that might mediate these effects. Male rats were tested for conditioned place preference following temporary inactivation of the anterior or posterior PVT with local injections of the GABAB and GABAA agonists, baclofen+muscimol. They were tested for sucrose seeking under a fixed ratio 3 (FR3) schedule of reinforcement and after extinction, following injection into the posterior PVT of baclofen+muscimol or saline vehicle. Finally, quantitative real-time PCR was used to examine local neuropeptide gene expression following injection into the posterior PVT of baclofen+muscimol or saline vehicle. Conditioned place preference was induced by temporary inactivation of the posterior but not anterior PVT. While sucrose seeking under an FR3 schedule of reinforcement was unaffected by inactivation of the posterior PVT, reinstatement of sucrose seeking was promoted by posterior PVT inactivation. Local gene expression of pituitary adenylate cyclase-activating polypeptide (PACAP), but not enkephalin or neurotensin, was reduced following inactivation of the posterior PVT. Temporary inactivation of the posterior PVT affects both affect and motivation as well as local gene expression of PACAP. These results suggest that the posterior PVT is one brain region that may participate in both major aspects of reward.
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影响因子：
4.2
作者：
Browning, Jenny R.;Jansen, Heiko T.;Sorg, Barbara A.
通讯作者：
Sorg, Barbara A.
DOI：
10.1111/acer.13826
发表时间：
2018-09
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Gupta A;Gargiulo AT;Curtis GR;Badve PS;Pandey S;Barson JR
通讯作者：
Barson JR
影响因子：
2.5
作者：
Barson JR;Leibowitz SF
通讯作者：
Leibowitz SF
影响因子：
2.7
作者：
Guy, Elizabeth G.;Choi, Eugene;Pratt, Wayne E.
通讯作者：
Pratt, Wayne E.
影响因子：
3
作者：
Barson JR;Mack NR;Gao WJ
通讯作者：
Gao WJ