The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature.
The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature.
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DOI：
10.3390/ijms18102028
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发表时间：
2017-10-03
影响因子：
5.6
通讯作者：
Stanewsky R
中科院分区：
文献类型：
--
作者：
Roessingh S;Stanewsky R
trpA1编码一个热敏瞬时受体电位通道（TRP通道），该通道在选择首选温度和避免有害热方面起作用。在这篇综述中，我们讨论了TRPA1在果蝇节律行为控制中的作用的证据。下午的活动水平和节律性温度偏好都受TRPA1调节。相比之下，TRPA1对于昼夜节律时钟的温度同步是必不可少的。我们讨论了trpa1介导的温度对节律行为影响的神经元基础，并得出结论，它们是由部分重叠但不同的神经元回路介导的。我们之前已经证明TRPA1是在温暖的温度循环下维持午睡睡眠所必需的。在这里，我们提出了新的数据调查神经元回路负责这种调节。首先，我们讨论了在识别负责神经元方面仍然存在的困难。其次，我们讨论了时钟神经元（s-LNv/DN1网络）在温度驱动的午睡睡眠调节中的作用，并强调了TRPA1在其中的作用。最后，我们讨论了午睡睡眠的两性二态性，并提出s-LNv/DN1时钟网络可能在环境信息、交配状态和其他内部驱动的整合中发挥作用，以适当地驱动适应性睡眠/觉醒行为。
trpA1 encodes a thermosensitive transient receptor potential channel (TRP channel) that functions in selection of preferred temperatures and noxious heat avoidance. In this review, we discuss the evidence for a role of TRPA1 in the control of rhythmic behaviours in Drosophila melanogaster. Activity levels during the afternoon and rhythmic temperature preference are both regulated by TRPA1. In contrast, TRPA1 is dispensable for temperature synchronisation of circadian clocks. We discuss the neuronal basis of TRPA1-mediated temperature effects on rhythmic behaviours, and conclude that they are mediated by partly overlapping but distinct neuronal circuits. We have previously shown that TRPA1 is required to maintain siesta sleep under warm temperature cycles. Here, we present new data investigating the neuronal circuit responsible for this regulation. First, we discuss the difficulties that remain in identifying the responsible neurons. Second, we discuss the role of clock neurons (s-LNv/DN1 network) in temperature-driven regulation of siesta sleep, and highlight the role of TRPA1 therein. Finally, we discuss the sexual dimorphic nature of siesta sleep and propose that the s-LNv/DN1 clock network could play a role in the integration of environmental information, mating status and other internal drives, to appropriately drive adaptive sleep/wake behaviour.
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