Emerging adjuvants for intradermal vaccination.
Emerging adjuvants for intradermal vaccination.
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DOI：
10.1016/j.ijpharm.2022.122559
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发表时间：
2023-02-05
影响因子：
5.8
通讯作者：
Chen, Xinyuan
中科院分区：
文献类型：
--
作者：
Chen, Xinyuan
关键词：
大多数疫苗已被递送到肌肉组织中。皮肤含有大量抗原递呈细胞，被认为是疫苗输送的免疫原性更强的部位。皮内给药已被批准用于提高流感疫苗的效力和节省流感疫苗剂量。为了应对最近的猴痘爆发，皮内注射也已被批准，以扩大有限的猴痘疫苗剂量，使更多的高危人群免疫。疫苗佐剂的引入有望进一步提高皮内疫苗的效力并节省更多的疫苗剂量。然而，皮内接种比肌内接种与更显著的局部反应相关。因此，适合于加强皮内接种的佐剂需要具有良好的局部安全性而不诱导明显的局部反应。本文介绍了目前批准的人用疫苗中的佐剂及其皮内给药的相对反应原性，并介绍了新出现的具有良好局部安全性的化学和物理佐剂，以促进皮内接种。本文还介绍了物理佐剂开发的理由、物理佐剂的种类以及物理佐剂在加强皮内免疫方面的独特优势。
The majority of vaccines have been delivered into the muscular tissue. Skin contains large amounts of antigen-presenting cells and has been recognized as a more immunogenic site for vaccine delivery. Intradermal delivery has been approved to improve influenza vaccine efficacy and spare influenza vaccine doses. In response to the recent monkeypox outbreak, intradermal delivery has been also approved to stretch the limited monkeypox vaccine doses to immunize more people at risk. Incorporation of vaccine adjuvants is promising to further increase intradermal vaccine efficacy and spare more vaccine doses. Yet, intradermal vaccination is associated with more significant local reactions than intramuscular vaccination. Thus, adjuvants suitable to boost intradermal vaccination need to have a good local safety without inducing overt local reactions. This review introduces currently approved adjuvants in licensed human vaccines and their relative reactogenicity for intradermal delivery and then introduces emerging chemical and physical adjuvants with a good local safety to boost intradermal vaccination. The rational to develop physical adjuvants, the types of physical adjuvants, and the unique advantages of physical adjuvants to boost intradermal vaccination are also introduced in this review.
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影响因子：
6.2
作者：
Bode C;Zhao G;Steinhagen F;Kinjo T;Klinman DM
通讯作者：
Klinman DM
影响因子：
4.4
作者：
Ahlberg V;Hjertner B;Wallgren P;Hellman S;Lövgren Bengtsson K;Fossum C
通讯作者：
Fossum C
影响因子：
3.7
作者：
Kashiwagi S;Yuan J;Forbes B;Hibert ML;Lee EL;Whicher L;Goudie C;Yang Y;Chen T;Edelblute B;Collette B;Edington L;Trussler J;Nezivar J;Leblanc P;Bronson R;Tsukada K;Suematsu M;Dover J;Brauns T;Gelfand J;Poznansky MC
通讯作者：
Poznansky MC
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
DOI：
10.4049/jimmunol.1601873
发表时间：
2017-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Morse K;Kimizuka Y;Chan MPK;Shibata M;Shimaoka Y;Takeuchi S;Forbes B;Nirschl C;Li B;Zeng Y;Bronson RT;Katagiri W;Shigeta A;Sîrbulescu RF;Chen H;Tan RYY;Tsukada K;Brauns T;Gelfand J;Sluder A;Locascio JJ;Poznansky MC;Anandasabapathy N;Kashiwagi S
通讯作者：
Kashiwagi S