Ambient air pollution and pregnancy outcomes: a review of the literature.
Ambient air pollution and pregnancy outcomes: a review of the literature.
复制标题
DOI：
10.1289/ehp.6362
复制
发表时间：
2005-04
影响因子：
10.4
通讯作者：
Bobak M
中科院分区：
文献类型：
--
作者：
Srám RJ;Binková B;Dejmek J;Bobak M
在过去十年左右的时间里，大量研究调查了环境空气污染对出生结果可能产生的不利影响。我们回顾了这些研究，这些研究是通过对主要科学数据库的系统检索确定的。几乎所有经审查的研究都是以人口为基础的，关于暴露于空气污染的资料来自例行监测来源。总的来说，有证据表明空气污染对不同的出生结果有不利影响，但证据的强度在不同的结果之间存在差异。证据足以推断出颗粒空气污染与新生儿后期呼吸道死亡之间的因果关系。对于空气污染和出生体重，证据表明存在因果关系，但需要进一步研究来确认影响及其大小，并澄清怀孕最脆弱的时期和不同污染物的作用。对于早产和胎儿宫内发育迟缓（IUGR）的证据还不足以推断因果关系，但现有的证据证明了进一步的研究。分子流行病学研究表明，可能的生物学机制对出生体重，早产和IUGR的影响，并支持污染和这些出生结果之间的关系是真实的。对于出生缺陷，迄今为止的证据基础不足以得出结论。就暴露于特定污染物而言，颗粒物似乎是婴儿死亡的最重要因素，对IUGR的影响似乎与多环芳烃有关，但现有证据无法精确识别不同的污染物或暴露时间，可能导致不良妊娠结局。
Over the last decade or so, a large number of studies have investigated the possible adverse effects of ambient air pollution on birth outcomes. We reviewed these studies, which were identified by a systematic search of the main scientific databases. Virtually all reviewed studies were population based, with information on exposure to air pollution derived from routine monitoring sources. Overall, there is evidence implicating air pollution in adverse effects on different birth outcomes, but the strength of the evidence differs between outcomes. The evidence is sufficient to infer a causal relationship between particulate air pollution and respiratory deaths in the postneonatal period. For air pollution and birth weight the evidence suggests causality, but further studies are needed to confirm an effect and its size and to clarify the most vulnerable period of pregnancy and the role of different pollutants. For preterm births and intrauterine growth retardation (IUGR) the evidence as yet is insufficient to infer causality, but the available evidence justifies further studies. Molecular epidemiologic studies suggest possible biologic mechanisms for the effect on birth weight, premature birth, and IUGR and support the view that the relation between pollution and these birth outcomes is genuine. For birth defects, the evidence base so far is insufficient to draw conclusions. In terms of exposure to specific pollutants, particulates seem the most important for infant deaths, and the effect on IUGR seems linked to polycyclic aromatic hydrocarbons, but the existing evidence does not allow precise identification of the different pollutants or the timing of exposure that can result in adverse pregnancy outcomes.
登录
查看更多内容
影响因子：
5.4
作者：
Bobak, M;Leon, DA
通讯作者：
Leon, DA
影响因子：
20.8
作者：
DOCKERY, DW;POPE, CA
通讯作者：
POPE, CA
影响因子：
5
作者：
COLLINS, JJ;KASAP, HS;HOLLAND, WW
通讯作者：
HOLLAND, WW
DOI：
10.1016/s0027-5107(02)00312-3
发表时间：
2003-04-09
影响因子：
2.3
作者：
Binkovdá, B;Cerná, M;Srám, RJ
通讯作者：
Srám, RJ
影响因子：
10.4
作者：
Carpenter DO;Arcaro K;Spink DC
通讯作者：
Spink DC