Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals
Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals
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年轻海洛因依赖者的灰质密度与海洛因使用时间呈负相关
DOI：
10.1016/j.bandc.2009.08.014
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发表时间：
2009-12
影响因子：
2.5
通讯作者：
Shi, JF
中科院分区：
文献类型：
--
作者：
Liu, YJ;Lee, TMC;Weng, XC;Yuan, Y;Yuan, F;Zou, ZL;Zhu, ZD;Shi, JF
大量的研究证明了吸毒者的前额叶和前扣带皮层的认知障碍和活动减退。然而，鸦片依赖与海洛因使用者大脑结构变化之间的关系在很大程度上是未知的。在本研究中，我们用基于体素形态学的方法测量了30名戒毒5个月的海洛因依赖终生个体和34名健康参与者的灰质密度。与健康组相比，海洛因依赖者的前额叶、颞叶和扣带皮层的DGM显著降低。重要的是，在控制了年龄、受教育程度和性别因素以及尼古丁使用和海洛因戒断持续时间的偏相关分析中，海洛因依赖个体的海洛因使用持续时间与DGM呈负相关。这些结果为海洛因依赖个体的结构异常提供了令人信服的证据，并进一步表明海洛因使用时间是导致脑损伤的关键因素。
Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage.
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影响因子：
3.4
作者：
Ersche, Karen D.;Fletcher, Paul C.;Roiser, Jonathan P.;Fryer, Tim D.;London, Mervyn;Robbins, Trevor W.;Sahakian, Barbara J.
通讯作者：
Sahakian, Barbara J.
影响因子：
4.2
作者：
Cowan, RL;Lyoo, IK;Renshaw, PF
通讯作者：
Renshaw, PF
影响因子：
3.5
作者：
Gabryelak Teresa;A. Anna;Przybylska Maria;Józwiak Zofia;B. Gerard
通讯作者：
Gabryelak Teresa;A. Anna;Przybylska Maria;Józwiak Zofia;B. Gerard
影响因子：
7.6
作者：
Sim, Minyoung E.;Lyoo, In Kyoon;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
影响因子：
4.2
作者：
Matochik, JA;Eldreth, DA;Bolla, KI
通讯作者：
Bolla, KI