Cytotoxic T cell specificity for respiratory syncytial virus proteins: fusion protein is an important target antigen.

Cytotoxic T cell specificity for respiratory syncytial virus proteins: fusion protein is an important target antigen.
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细胞毒性T细胞对呼吸道合胞病毒蛋白的特异性:融合蛋白是重要的靶抗原。

DOI:
10.1099/0022-1317-68-8-2177
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发表时间:
1987
期刊:
The Journal of general virology
影响因子:
--
通讯作者:
Askonas,BA
Askonas,BA
中科院分区:
--
文献类型:
--
作者:
Pemberton,RM;Cannon,MJ;Openshaw,PJ;Ball,LA;Wertz,GW;Askonas,BA

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我们研究了呼吸道合胞病毒(RSV)组分的BALB/c细胞毒性T(Tc)细胞的特异性,使用重组牛痘病毒(VV)编码几个单独的RSV蛋白。我们发现,不同的VV免疫产生以下Tc记忆细胞群体:高水平的RSV特异性Tc细胞诱导的融合蛋白VV,但低水平的诱导VV编码的RSV核蛋白。T细胞对附着糖蛋白(基质分子的一部分或1A内部蛋白)的识别较差。虽然融合蛋白VV诱导了高水平的融合蛋白特异性Tc细胞,但与由RSV感染引发的Tc细胞相比,它们在A2和8/60 RSV毒株之间显示出差的交叉反应性。
We examined the specificity of BALB/c cytotoxic T (Tc) cells for respiratory syncytial virus (RSV) components, using recombinant vaccinia viruses (VV) coding for several individual RSV proteins. We found that immunization with the different VVs yielded the following Tcmemory cell populations: high levels of RSV-specific Tccells were induced with the fusion protein VV, but low levels were induced with VV coding for the RSV nucleoprotein. Tccell recognition of attachment glycoprotein, part of the matrix molecule or 1A internal protein was poor. While high levels of fusion protein- specific Tccells were induced by the fusion protein VV, they showed poor crossreactivity between the A2 and 8/60 RSV strains compared with Tccells primed by RSV infection.
呼吸道合胞病毒持续感染的 Balb/c 细胞的发育:细胞表面存在核糖核蛋白 1
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