Maternal self-reported genital tract infections during pregnancy and the risk of selected birth defects.
Maternal self-reported genital tract infections during pregnancy and the risk of selected birth defects.
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DOI：
10.1002/bdra.20749
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Carter TC;Olney RS;Mitchell AA;Romitti PA;Bell EM;Druschel CM;National Birth Defects Prevention Study
生殖道感染在怀孕期间很常见，可导致包括早产和新生儿感染在内的不良后果。这项产生假设的研究调查了这些感染是否与选定的出生缺陷有关。我们进行了一项病例对照研究，5913名儿童被确定为对照组，12158名来自国家出生缺陷预防研究（1997-2004）的出生缺陷儿童。产妇访谈提供了从怀孕前一个月到妊娠早期结束期间发生的生殖道感染的数据。感染要么被归类为单一的整体暴露，要么被视为包括衣原体/淋病/盆腔炎的一个亚组。比值比（ORs）和95%置信区间（ci）使用无条件逻辑回归进行估计，并对潜在混杂因素进行调整。生殖道感染与双侧肾发育不全/发育不全（OR, 2.89; 95% CI, 1.11-7.50）、唇裂伴或不伴腭裂（OR, 1.46; 95% CI, 1.03-2.06）和横肢缺陷（OR, 1.84; 95% CI, 1.04-3.26）相关。衣原体/淋病/盆腔炎仅与唇裂相关（OR, 2.81; 95% CI, 1.39-5.69）。经多组比较调整后，这些发现无统计学意义。在解释这些发现时需要谨慎，因为可能对感染进行错误分类，有限的样本量限制了对治疗效果的考虑，以及偶然关联的可能性。虽然这些数据并不能为生殖道感染和出生缺陷之间的关联提供强有力的证据，但需要对这些相对常见的感染可能产生的影响进行进一步的研究。
Genital tract infections are common during pregnancy and can result in adverse outcomes including preterm birth and neonatal infection. This hypothesis-generating study examined whether these infections are associated with selected birth defects. We conducted a case-control study of 5913 children identified as controls and 12,158 cases with birth defects from the National Birth Defects Prevention Study (1997–2004). Maternal interviews provided data on genital tract infections that occurred from one month before pregnancy through the end of the first trimester. Infections were either grouped together as a single overall exposure or were considered as a subgroup that included chlamydia/gonorrhea/pelvic inflammatory disease. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression with adjustment for potential confounders. Genital tract infections were associated with bilateral renal agenesis/hypoplasia (OR, 2.89; 95% CI, 1.11–7.50), cleft lip with or without cleft palate (OR, 1.46; 95% CI, 1.03–2.06), and transverse limb deficiency (OR, 1.84; 95% CI, 1.04–3.26). Chlamydia/gonorrhea/pelvic inflammatory disease was associated with cleft lip only (OR, 2.81; 95% CI, 1.39–5.69). These findings were not statistically significant after adjustment for multiple comparisons. Caution is needed in interpreting these findings due to the possible misclassification of infection, the limited sample size that constrained consideration of the effects of treatment, and the possibility of chance associations. Although these data do not provide strong evidence for an association between genital tract infections and birth defects, additional research on the possible effects of these relatively common infections is needed.
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DOI：
10.1002/bdra.20480
发表时间：
2008-08-01
影响因子：
--
作者：
Acs, Nandor;Banhidy, Ferenc;Czeizel, Andrew E.
通讯作者：
Czeizel, Andrew E.
影响因子：
3.4
作者：
CaroPaton, T;Carvajal, A;Pinilla, ER
通讯作者：
Pinilla, ER
影响因子：
2.8
作者：
De Francesco, M. A.;Gargiulo, F.;Manca, N.
通讯作者：
Manca, N.
影响因子：
5
作者：
Cogswell, Mary E.;Bitsko, Rebecca H.;Reefhuis, Jennita
通讯作者：
Reefhuis, Jennita
影响因子：
7.7
作者：
Greenland, Sander
通讯作者：
Greenland, Sander