The role of the basal ganglia in learning and memory: insight from Parkinson's disease.
The role of the basal ganglia in learning and memory: insight from Parkinson's disease.
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DOI：
10.1016/j.nlm.2011.08.006
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发表时间：
2011-11
影响因子：
2.7
通讯作者：
Shohamy, Daphna
中科院分区：
文献类型：
--
作者：
Foerde, Karin;Shohamy, Daphna
人们早就知道记忆不是一个单一的过程。相反，有不同种类的记忆，由不同的神经系统支持。这一想法源于早期发现，在不同大脑区域选择性损伤的患者中，记忆障碍的模式是可分离的。这些研究强调了基底神经节在非陈述性记忆中的作用，如程序或习惯学习，与内侧颞叶在陈述性记忆中的已知作用形成对比。近年来，神经科学多个领域的重大进展揭示了基底神经节在动机和决策中的重要作用。这些发现导致了关于基底神经节在学习中的作用的新发现，并强调了多巴胺在特定学习形式中的重要作用。在这里，我们回顾了这些最新的进展，重点是帕金森病患者学习研究的新发现。我们讨论了这些发现如何促进当前理论的发展，远离强调记忆内容的可描述性的帐户，并专注于由不同的大脑区域进行的特定计算。最后，我们讨论了新的挑战，出现在面对积累的证据，动态和相互关联的记忆系统，共同促进学习。
It has long been known that memory is not a single process. Rather, there are different kinds of memory that are supported by distinct neural systems. This idea stemmed from early findings of dissociable patterns of memory impairments in patients with selective damage to different brain regions. These studies highlighted the role of the basal ganglia in non-declarative memory, such as procedural or habit learning, contrasting it with the known role of the medial temporal lobes in declarative memory. In recent years, major advances across multiple areas of neuroscience have revealed an important role for the basal ganglia in motivation and decision making. These findings have led to new discoveries about the role of the basal ganglia in learning and highlighted the essential role of dopamine in specific forms of learning. Here we review these recent advances with an emphasis on novel discoveries from studies of learning in patients with Parkinson's disease. We discuss how these findings promote the development of current theories away from accounts that emphasize the verbalizability of the contents of memory and towards a focus on the specific computations carried out by distinct brain regions. Finally, we discuss new challenges that arise in the face of accumulating evidence for dynamic and interconnected memory systems that jointly contribute to learning.
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DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A
影响因子：
2.6
作者：
Cohn, Melanie;Moscovitch, Morris;Davidson, Patrick S. R.
通讯作者：
Davidson, Patrick S. R.
影响因子：
25
作者：
Cohen, Michael X.;Schoene-Bake, Jan-Christoph;Weber, Bernd
通讯作者：
Weber, Bernd
影响因子：
2.5
作者：
Aron, AR;Shohamy, D;Poldrack, RA
通讯作者：
Poldrack, RA
影响因子：
64.8
作者：
Brainard, MS;Doupe, AJ
通讯作者：
Doupe, AJ