Polycystic ovary syndrome is associated with atherogenic changes in lipoprotein particle number and size independent of body weight.
Polycystic ovary syndrome is associated with atherogenic changes in lipoprotein particle number and size independent of body weight.
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DOI：
10.1111/j.1365-2265.2011.04015.x
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发表时间：
2011-07
影响因子：
3.2
通讯作者：
Sam S
中科院分区：
文献类型：
--
作者：
Sidhwani S;Scoccia B;Sunghay S;Stephens-Archer CN;Mazzone T;Sam S
脂蛋白颗粒数量和大小的不良变化在胰岛素抵抗中很常见，并与心血管风险增加有关。PCOS缺乏关于脂蛋白颗粒数量和大小的综合信息，以及这些参数与体重、胰岛素抵抗和高雄激素血症的关系。我们验证了PCOS与脂蛋白谱的动脉粥样硬化变化相关的假设，并研究了胰岛素抵抗和雄激素在这些动脉粥样硬化变化中的作用。在美国某学术医学中心临床研究中心进行的病例对照研究。从25名多囊卵巢综合征妇女和25名年龄和BMI相似的对照组妇女中获取空腹血。采用核磁共振法测定各组脂蛋白颗粒数和大小，并进行组间比较。两组患者的平均BMI均小于30 kg/m2 （P=0.33）。PCOS患者VLDL颗粒数增加（P=0.005）， LDL颗粒数增加（P=0.02）， HDL颗粒数减少（P=0.04）。LDL大小呈临界降低（P=0.09）。在调整了种族、烟酒摄入量和运动后，这些差异仍然存在。在逐步回归模型中，生物可利用睾酮是LDL胆固醇、甘油三酯、VLDL和LDL颗粒数的唯一预测因子。SHBG是LDL和HDL大小的唯一预测因子。与体重无关，多囊卵巢综合征与脂蛋白谱变化相关，从而增加心血管疾病的风险。这些变化主要出现在非肥胖组的女性中，而且与雄激素的关系比空腹胰岛素的关系更密切。
Adverse changes in lipoprotein particle number and size are common with insulin resistance and are associated with increased cardiovascular risk. Comprehensive information regarding lipoprotein particle number and size, and how these parameters relate to body weight, insulin resistance and hyperandrogenemia is lacking in PCOS. We tested the hypothesis that PCOS is associated with atherogenic changes in lipoprotein profile independent of body weight and examined the role of insulin resistance and androgens in these atherogenic changes. Case-control study performed at Clinical Research Center at an Academic Medical Center in United States. Fasting Blood was obtained from 25 PCOS and 25 control women of similar age and BMI. Lipoprotein particle number and size was determined by nuclear magnetic resonance and compared between the groups. The mean BMI for both groups was less than 30 kg/m2 (P=0.33). Women with PCOS had an increase in VLDL particle number (P=0.005), LDL particle number (P=0.02) and a decrease in HDL size (P=0.04). LDL size was borderline decreased (P=0.09). These differences persisted after adjustment for ethnicity, alcohol and tobacco intake and exercise. In stepwise regression models, bioavailable testosterone was the only predictor of LDL cholesterol, triglyceride, VLDL and LDL particle number. SHBG was the only predictor of LDL and HDL size. Independent of body weight, PCOS was associated with changes in lipoprotein profile that increases risk for cardiovascular disease. These changes were present in a mostly non-obese group of women and were more closely related to androgens than fasting insulin.
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影响因子：
37.8
作者：
Lamarche, B;Tchernof, A;Despres, JP
通讯作者：
Despres, JP
影响因子：
5.9
作者：
Legro, RS;Kunselman, AR;Dunaif, A
通讯作者：
Dunaif, A
影响因子：
7.7
作者：
Garvey, WT;Kwon, S;Liao, YL
通讯作者：
Liao, YL
DOI：
10.1161/01.atv.0000209577.04246.c0
发表时间：
2006-04-01
影响因子：
8.7
作者：
Watanabe, H;Söderlund, S;Taskinen, MR
通讯作者：
Taskinen, MR
影响因子：
8.7
作者：
Freedman, DS;Otvos, JD;Walker, JA
通讯作者：
Walker, JA