The beginning of connectomics: a commentary on White et al. (1986) 'The structure of the nervous system of the nematode Caenorhabditis elegans'.
The beginning of connectomics: a commentary on White et al. (1986) 'The structure of the nervous system of the nematode Caenorhabditis elegans'.
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DOI：
10.1098/rstb.2014.0309
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发表时间：
2015-04-19
期刊：
影响因子：
--
通讯作者：
Emmons SW
中科院分区：
文献类型：
--
作者：
Emmons SW
白色等人的文章“秀丽隐杆线虫的神经系统结构”（又名"蠕虫的思想“），第一次发表了动物神经系统中突触连接的完整集合。这项工作是作为一项计划的一部分进行的，该计划开始了解基因如何决定神经系统的结构以及神经系统如何创造行为。它成为C. elegans研究，从那时起，它为生物学的所有领域提供了见解。26年过去了，计算机的发展，特别是更强大的计算机，使这类新的研究成为可能。人们希望有一天，对突触结构、连接体的了解，以及许多其他研究的结果，将导致对人类大脑的理解。这篇评论是为庆祝皇家学会《哲学汇刊》创刊350周年而写的。
The article ‘Structure of the nervous system of the nematode Caenorhabditis elegans' (aka ‘The mind of a worm’) by White et al., published for the first time the complete set of synaptic connections in the nervous system of an animal. The work was carried out as part of a programme to begin to understand how genes determine the structure of a nervous system and how a nervous system creates behaviour. It became a major stimulus to the field of C. elegans research, which has since contributed insights into all areas of biology. Twenty-six years elapsed before developments, notably more powerful computers, made new studies of this kind possible. It is hoped that one day knowledge of synaptic structure, the connectome, together with results of many other investigations, will lead to an understanding of the human brain. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.
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影响因子：
11.4
作者：
FIRE, A
通讯作者：
FIRE, A
影响因子：
2.7
作者：
CHALFIE, M;SULSTON, J
通讯作者：
SULSTON, J
影响因子：
2.7
作者：
ALBERTSON, DG;SULSTON, JE;WHITE, JG
通讯作者：
WHITE, JG
影响因子：
56.9
作者：
Beets, Isabel;Janssen, Tom;Schoofs, Liliane
通讯作者：
Schoofs, Liliane
影响因子：
56.9
作者：
CHALFIE, M;TU, Y;PRASHER, DC
通讯作者：
PRASHER, DC