Enhancing plasticity through repeated rTMS sessions: the benefits of a night of sleep.
Enhancing plasticity through repeated rTMS sessions: the benefits of a night of sleep.
复制标题
DOI：
10.1016/j.clinph.2010.05.019
复制
发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
--
作者：
Cohen DA;Freitas C;Tormos JM;Oberman L;Eldaief M;Pascual-Leone A
先前的研究表明，20 Hz重复经颅磁刺激（rTMS）的皮质脊髓促进作用在第一次rTMS后24小时的第二次rTMS期间更大。我们试图确定这种变形性是否依赖于睡眠-觉醒/昼夜节律周期的特定阶段。20名健康参与者在手部运动皮层（M1）上接受了两次20 Hz rTMS，间隔12小时，全天或过夜。基线皮质脊髓兴奋性没有组或会话的差异。第1阶段的时间不影响rTMS后兴奋性的相对增加。然而，在第二次rTMS会议的兴奋性增加是2倍以上的过夜组。当一个晚上的睡眠遵循rTMS到M1，在M1中诱导随后的可塑性的能力增强，这表明睡眠-觉醒和/或昼夜节律依赖的调制过程的超可塑性。经颅磁刺激治疗神经精神疾病需要反复进行rTMS。我们的研究结果表明，相对于睡眠-觉醒/昼夜节律周期的会话时间可能是治疗累积效应的关键因素。使用这种模式的未来研究可能会提供对人类亚可塑性的机械见解，从而改进策略以增强非侵入性刺激疗法。
Previous work has demonstrated that corticospinal facilitation from 20Hz repetitive transcranial magnetic stimulation (rTMS) was greater during a second rTMS session 24 hours after the first. We sought to determine whether such metaplasticity is dependent on a particular phase of the sleep-wake/circadian cycle. Twenty healthy participants received two sessions of 20 Hz rTMS over the hand motor cortex (M1) spaced 12 hours apart, either over-day or overnight. Baseline corticospinal excitability did not differ by group or session. The time-of-day of Session 1 did not influence the relative increase in excitability following rTMS. However, the increase in excitability from the second rTMS session was 2-fold greater in the overnight group. When a night with sleep follows rTMS to M1, the capacity to induce subsequent plasticity in M1 is enhanced, suggesting sleep-wake and/or circadian-dependent modulation of processes of metaplasticity. TMS treatment of neuropsychiatric disorders entails repeated sessions of rTMS. Our findings suggest that the timing of sessions relative to the sleep-wake/circadian cycle may be a critical factor in the cumulative effect of treatment. Future studies using this paradigm may provide mechanistic insights into human metaplasticity, leading to refined strategies to enhance non-invasive stimulation therapies.
登录
查看更多内容
影响因子：
17.1
作者：
Cohen DA;Wang W;Wyatt JK;Kronauer RE;Dijk DJ;Czeisler CA;Klerman EB
通讯作者：
Klerman EB
DOI：
10.1111/j.1460-9568.2009.07001.x
发表时间：
2009-12-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Arrigoni E;Lu J;Vetrivelan R;Saper CB
通讯作者：
Saper CB
DOI：
10.1126/science.1166673
发表时间：
2009-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gilestro GF;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
56.9
作者：
KARNI, A;TANNE, D;SAGI, D
通讯作者：
SAGI, D
影响因子：
6.7
作者：
Kim, Deborah R.;Pesiridou, Angeliki;O'Reardon, John P.
通讯作者：
O'Reardon, John P.