The influence of serotonin transporter polymorphisms on cortical activity: a resting EEG study.
The influence of serotonin transporter polymorphisms on cortical activity: a resting EEG study.
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5-羟色胺转运蛋白多态性对皮质活性的影响：一项静止的脑电图研究。
DOI：
10.1186/1471-2202-12-33
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发表时间：
2011-04-20
期刊：
影响因子：
2.4
通讯作者：
Chen TJ
中科院分区：
文献类型：
--
作者：
Lee TW;Yu YW;Hong CJ;Tsai SJ;Wu HC;Chen TJ
5-羟色胺转运体基因（5-HTT）是多巴胺能神经传递的关键调节因子，与各种精神疾病有关。在遗传变异中，5-HTT基因连锁多态性区域（5-HTTLPR）和第二内含子（5-HTTVNTR）中的串联重复数目可变的多态性具有功能性后果。然而，它们对皮质振荡的遗传影响仍不清楚。本研究探讨了5-HTTLPR（L-等位基因携带者与非携带者）和5-HTTVNTR（10-重复等位基因携带者与非携带者）多态性对年轻女性群体局部神经活动的调节作用。从195名健康女性中收集血液样本和静息状态闭眼脑电图（EEG）信号，并分为2组，每组2组：L-等位基因携带者（N = 91）与5-HTTLPR非携带者和10-重复等位基因携带者（N = 25）与5-HTTVNTR非携带者。分析了18个电极在θ、α、β、γ、γ 1和γ 2频率下的平均功率。通过独立t检验进行组间统计，并通过非参数分析量化区域功效的全球趋势。在5-HTTVNTR基因型中，10个重复等位基因携带者在整个大脑的γ频率显示出显着低的区域功率。我们注意到一个一致的全球趋势，即5-HTT转录效率低的载体具有低的区域功率，无论频带如何。非参数分析证实了这一观察结果，5-HTTLPR和5-HTTVNTR的P值分别为3.071 × 10-8和1.459 × 10-12。我们的分析表明，低5-HTT活性的基因型与放松过程中较少的局部神经同步。在广泛的精神疾病的5-HTT的遗传脆弱性方面的影响进行了讨论。鉴于5-HTTVNTR的10-重复等位基因在我们的研究样本中的频率较低，还应考虑假阳性结果的可能性。
The serotonin transporter gene (5-HTT) is a key regulator of serotonergic neurotransmission and has been linked to various psychiatric disorders. Among the genetic variants, polymorphisms in the 5-HTT gene-linked polymorphic region (5-HTTLPR) and variable-number-of-tandem-repeat in the second intron (5-HTTVNTR) have functional consequences. However, their genetic impact on cortical oscillation remains unclear. This study examined the modulatory effects of 5-HTTLPR (L-allele carriers vs. non-carriers) and 5-HTTVNTR (10-repeat allele carriers vs. non-carriers) polymorphism on regional neural activity in a young female population. Blood samples and resting state eyes-closed electroencephalography (EEG) signals were collected from 195 healthy women and stratified into 2 sets of comparisons of 2 groups each: L-allele carriers (N = 91) vs. non-carriers for 5-HTTLPR and 10-repeat allele carriers (N = 25) vs. non-carriers for 5-HTTVNTR. The mean power of 18 electrodes across theta, alpha, beta, gamma, gamma1, and gamma2 frequencies was analyzed. Between-group statistics were performed by an independent t-test, and global trends of regional power were quantified by non-parametric analyses. Among 5-HTTVNTR genotypes, 10-repeat allele carriers showed significantly low regional power at gamma frequencies across the brain. We noticed a consistent global trend that carriers with low transcription efficiency of 5-HTT possessed low regional powers, regardless of frequency bands. The non-parametric analyses confirmed this observation, with P values of 3.071 × 10-8 and 1.459 × 10-12 for 5-HTTLPR and 5-HTTVNTR, respectively. Our analyses showed that genotypes with low 5-HTT activity are associated with less local neural synchronization during relaxation. The implication with respect to genetic vulnerability of 5-HTT across a broad range of psychiatric disorders is discussed. Given the low frequency of 10-repeat allele of 5-HTTVNTR in our research sample, the possibility of false positive findings should also be considered.
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影响因子：
56.9
作者：
HAYDON, PG;MCCOBB, DP;KATER, SB
通讯作者：
KATER, SB
影响因子：
2.6
作者：
Bismark, Andrew W.;Moreno, Francisco A.;Stewart, Jennifer L.;Towers, David N.;Coan, James A.;Oas, Jennifer;Erickson, Robert P.;Allen, John J. B.
通讯作者：
Allen, John J. B.
DOI：
10.1016/0013-4694(90)90168-j
发表时间：
1990-03-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
COBEN, LA;CHI, D;STORANDT, M
通讯作者：
STORANDT, M
影响因子：
5.7
作者：
Ahveninen, J;Kähkönen, S;Jääskeläinen, IP
通讯作者：
Jääskeläinen, IP
影响因子：
10.6
作者：
Bertolino, A;Arciero, G;Scarabino, T
通讯作者：
Scarabino, T