Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry.
Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry.
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DOI：
10.1016/j.biopsycho.2009.12.002
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发表时间：
2010-02
影响因子：
2.6
通讯作者：
Allen, John J. B.
中科院分区：
文献类型：
--
作者：
Bismark, Andrew W.;Moreno, Francisco A.;Stewart, Jennifer L.;Towers, David N.;Coan, James A.;Oas, Jennifer;Erickson, Robert P.;Allen, John J. B.
与5-羟色胺合成、运输、识别或降解相关的基因的多态性变异可能会传达5-羟色胺系统结构的微妙变化，这些变化可能会使个体在面临生活压力时处于精神病理学的风险中。三个关键的5-羟色胺等位基因和额叶脑电不对称，一个假定的抑郁症的内表型之间的关系进行了研究。风险等位基因被假设为预测相对更大的右额叶脑活动，无论目前的临床状态。313名大学年龄段的个人，跨越一系列的抑郁严重程度，从没有神经病学的临床意义的水平，参与了样本。静息脑电图（EEG）活动记录从64头皮部位在四个场合分开至少24小时（两个8分钟的记录会话发生在每一个场合）。计算每个会话的同源位点之间的α幂不对称性分数，然后取平均值以形成每对的不对称性的性状度量。对HTR 1A、HTR 2A和HTTLPR基因进行基于PCR的基因分型。HTR 1A基因的变异与EEG不对称性有关，无论是否有抑郁症史。与具有至少一个非风险等位基因的受试者相比，具有纯合HTR 1A风险等位基因的受试者在位点F7/F8、F5/F6和F1/F2处具有显著更大的相对右额叶活动。总之，HTR 1A的变化可以影响特征水平的大脑活动，这最终可能表明精神病理学的风险。
Polymorphic variations in genes related to serotonin synthesis, transport, recognition, or degradation may convey subtle changes in serotonin system architecture that may place an individual at risk for psychopathology when faced with life stressors. The relationship between three key serotonin alleles and frontal brain electrical asymmetry, a putative endophenotype of depression, was examined. Risk alleles were hypothesized to predict relatively greater right frontal brain activity regardless of current clinical state. A sample of 313 college-age individuals, spanning a range of depressive severity from no symptomotology to clinically meaningful levels, participated. Resting encephalographic (EEG) activity was recorded from 64 scalp sites on four occasions separated by at least 24 hours (two 8-min recording sessions occurring at each occasion). Alpha power asymmetry scores between homologous sites were calculated for each session and then averaged to form a trait metric of asymmetry for each pair. PCR based genotyping was conducted for the HTR1A, HTR2A, and HTTLPR genes. Variations in the HTR1A gene were related to trait EEG asymmetry, regardless of any history of depression. Compared to subjects with at least one non-risk allele, subjects with homozygous HTR1A risk alleles had significantly greater relative right frontal activity at sites F7/F8, F5/F6, & F1/F2. In conclusion, variation in HTR1A can influence trait level brain activity, which may ultimately be indicative of risk for psychopathology.
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影响因子：
6.6
作者：
Allen, John J. B.;McKnight, Katherine M.;Moreno, Francisco A.;Demaree, Heath A.;Delgado, Pedro L.
通讯作者：
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通讯作者：
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作者：
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Quitkin, FM