Neuromodulation of reward-based learning and decision making in human aging.
Neuromodulation of reward-based learning and decision making in human aging.
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DOI：
10.1111/j.1749-6632.2011.06230.x
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发表时间：
2011-10
影响因子：
5.2
通讯作者：
Li SC
中科院分区：
文献类型：
--
作者：
Eppinger B;Hämmerer D;Li SC
在本文中，我们回顾了目前的文献，强调与年龄相关的多巴胺能和多巴胺能神经调节的下降和适应性目标导向行为的成人年龄差异之间的关系。具体来说，我们关注的证据表明，神经调节的缺陷有助于老年人在学习和决策方面的行为劣势。当奖励信息不确定或任务背景需要灵活适应不断变化的刺激-奖励突发事件时，这些缺陷尤其明显。此外，新出现的证据表明，在学习和决策过程中，如果行为的获得严重依赖于结果处理，则对奖励和厌恶结果的敏感性存在年龄相关差异。这些年龄相关的结果评价的不对称性，可以解释的年龄差异的相互作用的多巴胺能和多巴胺能神经调节。这一假设是基于最近的神经计算和精神药理学的方法，这表明多巴胺和血清素在调节接近行为和抑制控制之间的平衡方面起着相反的作用。研究整个成年期的行为适应性调节可能会为衰老的大脑如何响应其资源减少而发生功能性变化提供新的线索。
In this paper, we review the current literature to highlight relations between age-associated declines in dopaminergic and serotonergic neuromodulation and adult age differences in adaptive goal-directed behavior. Specifically, we focus on evidence suggesting that deficits in neuromodulation contribute to older adults’ behavioral disadvantages in learning and decision making. These deficits are particularly pronounced when reward information is uncertain or the task context requires flexible adaptations to changing stimulus–reward contingencies. Moreover, emerging evidence points to age-related differences in the sensitivity to rewarding and aversive outcomes during learning and decision making if the acquisition of behavior critically depends on outcome processing. These age-related asymmetries in outcome valuation may be explained by age differences in the interplay of dopaminergic and serotonergic neuromodulation. This hypothesis is based on recent neurocomputational and psychopharmacological approaches, which suggest that dopamine and serotonin serve opponent roles in regulating the balance between approach behavior and inhibitory control. Studying adaptive regulation of behavior across the adult life span may shed new light on how the aging brain changes functionally in response to its diminishing resources.
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影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
DOI：
10.1073/pnas.0802127105
发表时间：
2008-09-30
影响因子：
11.1
作者：
Dreher, Jean-Claude;Meyer-Lindenberg, Andreas;Berman, Karen Faith
通讯作者：
Berman, Karen Faith
影响因子：
--
作者：
ANTONINI, A;LEENDERS, KL;LOCHER, J
通讯作者：
LOCHER, J
影响因子：
5.3
作者：
Cools, R;Clark, L;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
3.7
作者：
Clarke, H. F.;Walker, S. C.;Roberts, A. C.
通讯作者：
Roberts, A. C.