A selective working memory impairment after transcranial direct current stimulation to the right parietal lobe.
A selective working memory impairment after transcranial direct current stimulation to the right parietal lobe.
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DOI：
10.1016/j.neulet.2010.05.087
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发表时间：
2010-08-02
影响因子：
2.5
通讯作者：
Olson IR
中科院分区：
文献类型：
--
作者：
Berryhill ME;Wencil EB;Branch Coslett H;Olson IR
The role of the posterior parietal cortex in working memory (WM) is poorly understood. We previously found that patients with parietal lobe damage exhibited a selective WM impairment on recognition but not recall tasks. We hypothesized that this dissociation reflected strategic differences in the utilization of attention. One concern was that these findings, and our subsequent interpretation, would not generalize to normal populations because of the patients older age, progressive disease processes, and/or possible brain reorganization following injury. To test whether our findings extended to a normal population we applied transcranial direct current stimulation (tDCS) to right inferior parietal cortex. tDCS is a technique by which low electric current applied to the scalp modulates the resting potentials of underlying neural populations and can be used to test structure-function relationships. Eleven normal young adults received cathodal, anodal, or sham stimulation over right inferior posterior parietal cortex and then performed separate blocks of an object WM task probed by recall or recognition. The results showed that cathodal stimulation selectively impaired WM on recognition trials. These data replicate and extend our previous findings of preserved WM recall and impaired WM recognition in patients with parietal lobe lesions.
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影响因子：
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通讯作者：
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DOI：
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