Investigation of silk as a phantom material for ultrasound and photoacoustic imaging.
Investigation of silk as a phantom material for ultrasound and photoacoustic imaging.
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DOI：
10.1016/j.pacs.2022.100416
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发表时间：
2022-12
期刊：
影响因子：
7.9
通讯作者：
Mallidi, Srivalleesha
中科院分区：
文献类型：
--
作者：
Nguyen, Christopher D.;Edwards, Skye A.;Iorizzo, Tyler W.;Longo, Brooke N.;Yaroslavsky, Anna N.;Kaplan, David L.;Mallidi, Srivalleesha
关键词：
生物医学成像系统的全面表征需要易于捏造的幻象，并且可以模仿人体组织。明胶之类的材料会经历快速降解，而聚合物基材料（例如聚乙烯醇）没有用于产生生物工程的导电性可以在这里结合细胞的组织。散射减少，测量杨氏模量。在400–1200 nm的波长范围内，丝绸基材料可以长期存储，而声性和光学性质无变化，因此可以使用超声和光声系统的性能。
Comprehensive characterization of biomedical imaging systems require phantoms that are easy to fabricate and can mimic human tissue. Additionally, with the arrival of engineered tissues, it is key to develop phantoms that can mimic bioengineered samples. In ultrasound and photoacoustic imaging, water-soluble phantom materials such as gelatin undergo rapid degradation while polymer-based materials such as polyvinyl alcohol are not conducive for generating bioengineered tissues that can incorporate cells. Here we propose silk protein-based hydrogels as an ultrasound and photoacoustic phantom material that has potential to provide a 3D environment for long-term sustainable cell growth. Common acoustic, optical, and biomechanical properties such as ultrasound attenuation, reduced scattering coefficient, and Young's modulus were measured. The results indicate that silk acoustically mimics many tissue types while exhibiting similar reduced optical scattering in the wavelength range of 400–1200 nm. Furthermore, silk-based materials can be stored long-term with no change in acoustic and optical properties, and hence can be utilized to assess the performance of ultrasound and photoacoustic systems.
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