The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors.
The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors.
复制标题
丝绸的产生生物学:探索丝绸生物材料对指导细胞行为的生物物理影响。
DOI:
10.3389/fbioe.2021.697981
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发表时间:
2021
影响因子:
5.7
通讯作者:
Abbott RD
中科院分区:
文献类型:
--
作者:
Kochhar D;DeBari MK;Abbott RD
Biophysical properties of the extracellular environment dynamically regulate cellular fates. In this review, we highlight silk, an indispensable polymeric biomaterial, owing to its unique mechanical properties, bioactive component sequestration, degradability, well-defined architectures, and biocompatibility that can regulate temporospatial biochemical and biophysical responses. We explore how the materiobiology of silks, both mulberry and non-mulberry based, affect cell behaviors including cell adhesion, cell proliferation, cell migration, and cell differentiation. Keeping in mind the novel biophysical properties of silk in film, fiber, or sponge forms, coupled with facile chemical decoration, and its ability to match functional requirements for specific tissues, we survey the influence of composition, mechanical properties, topography, and 3D geometry in unlocking the body’s inherent regenerative potential.
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影响因子:
10
作者:
Abbott RD;Wang RY;Reagan MR;Chen Y;Borowsky FE;Zieba A;Marra KG;Rubin JP;Ghobrial IM;Kaplan DL
通讯作者:
Kaplan DL
影响因子:
3.7
作者:
Dinis TM;Vidal G;Jose RR;Vigneron P;Bresson D;Fitzpatrick V;Marin F;Kaplan DL;Egles C
通讯作者:
Egles C
影响因子:
9.5
作者:
Ding, Zhaozhao;Fan, Zhihai;Kaplan, David L.
通讯作者:
Kaplan, David L.
影响因子:
56.9
作者:
Cukierman, E;Pankov, R;Yamada, KM
通讯作者:
Yamada, KM
影响因子:
9.5
作者:
Dhyani, Vartika;Singh, Neetu
通讯作者:
Singh, Neetu