Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
复制标题
产前镉暴露与中国新生儿白细胞端粒长度较短有关
DOI：
10.1186/s12916-019-1262-4
复制
发表时间：
2019-02
期刊：
影响因子：
9.3
通讯作者：
Shunqing Xu
中科院分区：
文献类型：
--
作者：
Lina Zhang;Lulu Song;Bingqing Liu;Mingyang Wu;Lulin Wang;Bin Zhang;Chao Xiong;Wei Xia;Yuanyuan Li;Zhongqiang Cao;Youjie Wang;Shunqing Xu
研究背景新生儿端粒长度（TL）被认为是未来疾病和终身健康的潜在标志物，但很少有流行病学研究探讨了生命早期TL的决定因素。这项研究的目的是调查是否有产前镉暴露和相对脐带血TL在中国newbors.MethodsParticipants之间的关联是410对来自前瞻性出生队列研究在武汉，中国，2013年11月和2015年3月之间进行。尿液样本采集自孕妇在机构分娩期间。采用电感耦合等离子体质谱法测定尿镉浓度。应用实时荧光定量聚合酶链反应技术检测脐带血白细胞基因组DNA的相对转移率。多元线性回归模型被用来估计产前尿镉浓度相对脐带血TL的影响。结果母亲尿镉浓度的几何平均值为0.68 μg/g肌酐。在多变量校正的线性回归模型中，母体尿镉浓度每增加一倍与6.83%（95%CI-11.44%，-1.97%;P= 0.006）的相对脐带血TL缩短相关。分层分析表明，产前尿镉与新生儿相关性TL之间的负相关在女婴和母亲< 29岁中更为明显，而婴儿性别差异无显著性（交互作用P = 0.907）和母亲年龄结论孕妇尿镉水平升高与脐带血TL缩短有关。研究结果为环境镉暴露的负面影响提供了更多的证据，并表明加速衰老或镉相关疾病可能在生命早期就开始开始。
BackgroundNewborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and relative cord blood TL in Chinese newborns.MethodsParticipants were 410 mother–newborn pairs drawn from a prospective birth cohort study conducted in Wuhan, China, between November 2013 and March 2015. Urine samples were collected from pregnant women during their period of institutional delivery. Urinary cadmium concentrations were measured by inductively coupled plasma mass spectrometry. The real-time quantitative polymerase chain reaction detection was used to measure relative TL using genomic DNA isolated from umbilical cord blood leukocytes. Multivariate linear regression models were used to estimate the effect of prenatal urinary cadmium concentration on relative cord blood TL.ResultsThe geometric mean of maternal urinary cadmium concentration was 0.68 μg/g creatinine. In the multivariate-adjusted linear regression model, per doubling of maternal urinary cadmium concentration was associated with 6.83% (95% CI − 11.44%, − 1.97%;P= 0.006) shorter relative cord blood TL. Stratified analyses indicated that the inverse association between prenatal urinary cadmium and newborn relative TL was more pronounced among female infants and mothers < 29 years, while there were no significant effect modification according to infant sex (Pfor interaction = 0.907) and maternal age (Pfor interaction = 0.797).ConclusionsThe findings indicated that increased maternal urinary cadmium was associated with shortened relative cord blood TL. The results provide more evidence of the negative effects of environmental cadmium exposure and suggest that accelerated aging or cadmium-related diseases may begin in early life.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
在健康、衰老和身体成分研究中，累积炎症负荷与白细胞端粒长度短有关。
影响因子：
3.7
作者：
O'Donovan A;Pantell MS;Puterman E;Dhabhar FS;Blackburn EH;Yaffe K;Cawthon RM;Opresko PL;Hsueh WC;Satterfield S;Newman AB;Ayonayon HN;Rubin SM;Harris TB;Epel ES;Health Aging and Body Composition Study
通讯作者：
Health Aging and Body Composition Study
DOI：
10.1016/s0145-4145(08)04003-3
发表时间：
2008
期刊：
Yearbook of Cardiology
影响因子：
--
作者：
B. Gersh
通讯作者：
B. Gersh
DOI：
10.32388/7z88wu
发表时间：
1989-11
期刊：
Definitions
影响因子：
--
作者：
C. Binkert;G. Heinrich;J. Schwander
通讯作者：
C. Binkert;G. Heinrich;J. Schwander
中国健康婴儿队列研究中母亲尿镉浓度与早产的关系
影响因子：
11.8
作者：
Jie Yang;Wenqian Huo;Bin Zhang;Tongzhang Zheng;Yuanyuan Li;Xinyun Pan;Wenyu Liu;Huailong Chang;Minmin Jiang;Aifen Zhou;Zhengmin Qian;Yanjian Wan;Wei Xia;Shunqing Xu
通讯作者：
Shunqing Xu