Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters.
Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters.
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DOI：
10.1016/j.actbio.2013.03.041
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发表时间：
2013-07
影响因子：
9.7
通讯作者：
Bettinger CJ
中科院分区：
文献类型：
--
作者：
Zhu C;Kustra SR;Bettinger CJ
合成生物可降解弹性体是一类新兴的材料，在支持生物可吸收医疗植入物的创新方面发挥着关键作用。本文介绍了一种可生物降解的弹性体聚(甘油-癸二酸酯)-肉桂酸酯(PGS-CINA)的合成和表征。在没有光引发剂的情况下，可以使用常见食品中的单体通过光二聚反应制备PGS-CINA。所得网络的杨氏模数为50.5千帕至152.1千帕，预计体外降解半衰期为90至140d。PGS-CINA弹性体本质上是细胞粘附性的，支持成纤维细胞的快速增殖。在所制备的PGS-CINA网络中，成纤维细胞的扩散和增殖在杨氏模数范围内受基质硬度的松散控制。PGS-Cina网络的热机械性能、生物降解性以及细胞附着和增殖的内在支持表明，PGS-Cina网络广泛应用于下一代生物可吸收材料，包括临时医疗器械和软组织工程支架。
Synthetic biodegradable elastomers are an emerging class of materials that play a critical role in supporting innovations in bioabsorbable medical implants. This work describes the synthesis and characterization of poly (glycerol-co-sebacate)-cinnamate (PGS-CinA), a biodegradable elastomer based on hyperbranched polyesters derivatized with pendant cinnamate groups. PGS-CinA can be prepared via photodimerization in the absence of photoinitiator using monomers that are found in common foods. The resulting network exhibits a Young’s modulus of 50.5 to 152.1 kPa and a projected in vitro degradation half-life time between 90 and 140 days. PGS-CinA elastomers are intrinsically cell adherent and support rapid proliferation of fibroblasts. Spreading and proliferation of fibroblasts are loosely governed by the substrate stiffness within the range of Young’s moduli in PGS-CinA networks that were prepared. The thermo-mechanical properties, biodegradability, and intrinsic support of cell attachment and proliferation suggest that PGS-CinA networks abroadly applicable for use in next generation bioabsorable materials including temporary medical devices and scaffolds for soft tissue engineering.
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